{"id":"gsk-biologicals-synflorix","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Injection site erythema"},{"rate":"5-20","effect":"Injection site swelling"},{"rate":"10-25","effect":"Fever"},{"rate":"20-40","effect":"Irritability"},{"rate":"15-35","effect":"Drowsiness"},{"rate":"10-20","effect":"Loss of appetite"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Synflorix contains polysaccharide antigens from 13 serotypes of Streptococcus pneumoniae conjugated to a protein carrier (protein D from Haemophilus influenzae type b), which enhances immunogenicity and T-cell dependent responses. The vaccine primes both humoral and cellular immunity to reduce the risk of invasive pneumococcal disease, pneumonia, and otitis media caused by vaccine-covered serotypes.","oneSentence":"Synflorix is a pneumococcal conjugate vaccine that stimulates immune responses against multiple serotypes of Streptococcus pneumoniae to prevent pneumococcal disease.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:47:37.016Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of invasive pneumococcal disease in infants and children"},{"name":"Prevention of pneumococcal otitis media"},{"name":"Prevention of pneumococcal pneumonia in pediatric populations"}]},"trialDetails":[{"nctId":"NCT01641133","phase":"PHASE3","title":"Primary Vaccination With Either Synflorix™ or Prevenar 13™ or Both Vaccines and Booster Vaccination With Synflorix™","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-09-04","conditions":"Infections, Streptococcal, 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