{"id":"gsk-biologicals-kinrix","safety":{"commonSideEffects":[{"rate":"10-50%","effect":"Injection site pain, redness, or swelling"},{"rate":"10-30%","effect":"Fever"},{"rate":"10-40%","effect":"Irritability or fussiness"},{"rate":"10-30%","effect":"Drowsiness"},{"rate":"5-15%","effect":"Loss of appetite"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Kinrix combines five inactivated vaccines (DTaP-IPV-HepB) in a single injection. It works by introducing inactivated or recombinant antigens from these five diseases, which trigger both humoral and cellular immune responses. This results in the production of specific antibodies and memory immune cells that protect against infection if exposure occurs.","oneSentence":"Kinrix is a combination vaccine that provides immunization against diphtheria, tetanus, pertussis, poliomyelitis, and hepatitis B by stimulating the immune system to produce protective antibodies against these pathogens.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:14:40.171Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Primary immunization against diphtheria, tetanus, pertussis, poliomyelitis, and hepatitis B in infants and children (ages 6 weeks to 6 years)"}]},"trialDetails":[{"nctId":"NCT00871117","phase":"PHASE3","title":"Immunogenicity and Safety of Kinrix + (Measles Mumps Rubella) MMR Vaccine With and Without Varicella Vaccine in Healthy Children 4-6 Years","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-03-31","conditions":"Tetanus, Acellular Pertussis, Diphtheria","enrollment":478}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"GSK Biologicals'Kinrix®","genericName":"GSK Biologicals'Kinrix®","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"Kinrix is a combination vaccine that provides immunization against diphtheria, tetanus, pertussis, poliomyelitis, and hepatitis B by stimulating the immune system to produce protective antibodies against these pathogens. Used for Primary immunization against diphtheria, tetanus, pertussis, poliomyelitis, and hepatitis B in infants and children (ages 6 weeks to 6 years).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}