{"id":"gsk-biologicals-influenza-vaccine-gsk2186877a","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or erythema"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an influenza vaccine, GSK2186877A works by presenting viral antigens to the immune system, triggering both humoral (antibody-mediated) and cellular immune responses. This primes the body to recognize and rapidly respond to natural influenza infection, reducing disease severity and transmission. The specific formulation and adjuvant strategy of GSK2186877A is designed to enhance immunogenicity compared to standard seasonal influenza vaccines.","oneSentence":"GSK2186877A is an influenza vaccine that stimulates the immune system to produce antibodies and cellular immunity against influenza virus strains.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:41.184Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of influenza infection in adults"}]},"trialDetails":[{"nctId":"NCT01096056","phase":"PHASE1","title":"Trial to Evaluate the Safety and the Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in Healthy Children","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2010-04-05","conditions":"Influenza","enrollment":40},{"nctId":"NCT00992784","phase":"PHASE3","title":"Study to Evaluate the Safety and Immunogenicity of GlaxoSmithKline Biologicals' Influenza Vaccine in Elderly People","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-10-15","conditions":"Influenza","enrollment":370},{"nctId":"NCT00938392","phase":"PHASE3","title":"Study to Evaluate the Immunogenicity and Safety of an Investigational Influenza Vaccine for the Elderly","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-07-30","conditions":"Influenza","enrollment":726},{"nctId":"NCT00760617","phase":"PHASE3","title":"Evaluation of Safety and Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Years and Older","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-10-06","conditions":"Influenza","enrollment":526},{"nctId":"NCT00772889","phase":"PHASE3","title":"Evaluation of the Safety and Immunogenicity of the Influenza Vaccine GSK2186877A in the Elderly","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-10-09","conditions":"Influenza","enrollment":971},{"nctId":"NCT00765076","phase":"PHASE3","title":"Clinical Study of the Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in People Aged 65 Years or Older","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-10-16","conditions":"Influenza","enrollment":192},{"nctId":"NCT00753272","phase":"PHASE3","title":"Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-09-15","conditions":"Influenza","enrollment":43695}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"GSK Biologicals' influenza vaccine GSK2186877A","genericName":"GSK Biologicals' influenza vaccine GSK2186877A","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"GSK2186877A is an influenza vaccine that stimulates the immune system to produce antibodies and cellular immunity against influenza virus strains. Used for Prevention of influenza infection in adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}