{"id":"grt9906","safety":{"commonSideEffects":[{"rate":null,"effect":"Taste disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"P2X3 receptors are ion channels expressed on nociceptive nerve fibers that mediate pain signaling when activated by ATP. By blocking P2X3, GRT9906 selectively inhibits pain transmission without affecting motor function or other sensory modalities. This mechanism makes it potentially useful for chronic pain conditions where P2X3 plays a significant role.","oneSentence":"GRT9906 is a selective antagonist of the P2X3 receptor that reduces pain signal transmission in sensory neurons.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T04:01:22.758Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic cough"},{"name":"Neuropathic pain"}]},"trialDetails":[{"nctId":"NCT03783910","phase":"PHASE2","title":"Efficacy and Safety of GRT9906 Tablets Compared to Placebo in Patients With Fibromyalgia","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2005-09-19","conditions":"Primary Fibromyalgia","enrollment":90},{"nctId":"NCT03776110","phase":"PHASE1","title":"Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GRT9906 Prolonged Release Tablets After Dose Escalation in Healthy Subjects","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2004-09-15","conditions":"Pharmacokinetics","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"GRT9906","genericName":"GRT9906","companyName":"Grünenthal GmbH","companyId":"gr-nenthal-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"GRT9906 is a selective antagonist of the P2X3 receptor that reduces pain signal transmission in sensory neurons. Used for Chronic cough, Neuropathic pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}