{"id":"group-4-in-part-b-and-part-c","rwe":[],"tags":[],"phase":"discontinued","safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[],"contraindications":[],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"status":"discontinued","trials":["NCT06918002","NCT03439514","NCT00323297","NCT01210495","NCT05712460","NCT01856595","NCT05375929","NCT03975647","NCT04801420","NCT02880371","NCT02603432","NCT04389632","NCT03334851","NCT01623752","NCT03915496","NCT05574010","NCT02780167","NCT01925274","NCT00630487","NCT01920061","NCT00502242","NCT00454298","NCT02663518","NCT07363694","NCT00721409"],"aliases":[],"patents":[],"pricing":[],"allNames":"group 4 in part b and part c","offLabel":[],"timeline":[{"date":"2008","type":"neutral","milestone":"Phase 1 Initiated","description":"Phase 1 trial (Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement) — Osteoarthritis"},{"date":"2008","type":"negative","milestone":"Phase 3 Initiated","description":"Phase 3 trial (Efficacy of Somatropin in Adult Patients With Isolated Growth Hormone Deficiency) — Growth Hormone Deficiency. Trial terminated early."},{"date":"2013","type":"neutral","milestone":"Phase 4 Initiated","description":"Phase 4 trial (Assess the Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Ar) — Pulmonary Arterial Hypertension"},{"date":"2013","type":"neutral","milestone":"Phase 2 Initiated","description":"Phase 2 trial (Study Of Letrozole With Or Without Palbociclib (PD-0332991) For The First-Line Treatment Of Hormone-) — Breast Cancer"}],"aiSummary":"I cannot provide an accurate summary because the drug name, mechanism of action, and approved indications are not specified in your request. Please provide the specific drug name, FDA mechanism text, and approved indication to generate an accurate clinical summary.","brandName":"Group 4 in Part B and Part C","companyId":"pfizer","ecosystem":[],"mechanism":{"target":"","novelty":"","modality":"","drugClass":"Dose 5 KAN-101 Intravenous (IV) infusion","explanation":"I need more information to provide an accurate explanation. Please specify: 1) The drug name, 2) The FDA mechanism of action text, and 3) The approved indication(s). 'Group 4 in Part B and Part C' appears to be a reference system rather than a drug identifier. Once you provide these details, I can create a clear, accessible explanation of how the drug works without using medical jargon or regulatory language.","oneSentence":"Dose 5 KAN-101 Intravenous (IV) infusion","technicalDetail":""},"commercial":null,"references":[],"biosimilars":[],"companyName":"Pfizer Inc.","competitors":[],"genericName":"group-4-in-part-b-and-part-c","indications":{"approved":[],"offLabel":[],"pipeline":[{"name":"Celiac Disease","phase":"discontinued","trialId":"","patients":null,"diseaseId":"gastroenterology---hepatology","trialName":"","primaryEndpoint":"","expectedCompletion":""}]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06918002","phase":"discontinued","title":"Elranatamab/Lenalidomide Consolidation and/or Elranatamab Maintenance Versus Standard of Care After ","status":"discontinued","sponsor":"Intergroupe Francophone du Myelome","isPivotal":false,"enrollment":824,"indication":"Multiple Myeloma, Newly 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Inc.","isPivotal":false,"enrollment":105,"indication":"Pulmonary Arterial Hypertension","completionDate":"2013-08","primaryEndpoint":"To assess the efficacy and safety of sildenafil when added to patients with PAH who are taking bosentan as all or part of their background therapy."},{"nctId":"NCT01210495","phase":"discontinued","title":"Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma","status":"discontinued","sponsor":"Pfizer","isPivotal":false,"enrollment":224,"indication":"Hepatocellular Carcinoma","completionDate":"2014-03","primaryEndpoint":"The study is designed to demonstrate that axitinib plus best supportive care is superior to placebo plus best supportive care in prolonging survival in patients with advanced hepatocellular carcinoma."},{"nctId":"NCT05712460","phase":"discontinued","title":"A Study to Assess the Safety, Effects and Palatability of Sisunatovir in Healthy Adult 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Adu","status":"discontinued","sponsor":"Pfizer","isPivotal":false,"enrollment":625,"indication":"Lyme Borreliosis","completionDate":"2022-03","primaryEndpoint":"VLA15-221 is a Phase 2 study, which will be conducted in two parts: Main Study Phase (Part A) and Booster Phase (Part B)."},{"nctId":"NCT02880371","phase":"discontinued","title":"A Study of ARRY-382 in Combination With Pembrolizumab for the Treatment of Patients With Advanced So","status":"discontinued","sponsor":"Pfizer","isPivotal":false,"enrollment":82,"indication":"Advanced Solid Tumors","completionDate":"2019-09","primaryEndpoint":"This is an open-label, multicenter Phase 1b/2 study to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of ARRY-382 in combination with pembrolizumab in adult patients"},{"nctId":"NCT02603432","phase":"discontinued","title":"A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN 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