{"id":"grazax-r","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral pruritus"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Ear pruritus"},{"rate":null,"effect":"Mouth edema"},{"rate":null,"effect":"Local allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Grazax-R contains a standardized grass pollen allergen extract administered sublingually to induce immune tolerance. The drug works by shifting the immune response from allergic (Th2-mediated) to regulatory/tolerant (Treg-mediated), reducing allergic symptoms upon natural grass pollen exposure. This sublingual immunotherapy approach allows for at-home administration and aims to provide long-term symptom relief and reduced medication dependence.","oneSentence":"Grazax-R is an oral immunotherapy that desensitizes the immune system to grass pollen allergens through gradual exposure under the tongue.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:21.131Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Grass pollen-induced allergic rhinitis and/or allergic asthma"}]},"trialDetails":[{"nctId":"NCT00408616","phase":"PHASE3","title":"Efficacy and Safety of Grazax in Children","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2006-11","conditions":"Allergy","enrollment":253},{"nctId":"NCT00298701","phase":"PHASE1","title":"Tolerability of Grazax-R in Children","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2006-02","conditions":"Allergy","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Grazax-R","genericName":"Grazax-R","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Biologic","firstApprovalDate":"","aiSummary":"Grazax-R is an oral immunotherapy that desensitizes the immune system to grass pollen allergens through gradual exposure under the tongue. Used for Grass pollen-induced allergic rhinitis and/or allergic asthma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}