{"id":"grazax-aerius","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral pruritus"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Ear pruritus"},{"rate":null,"effect":"Mouth edema"},{"rate":null,"effect":"Somnolence (from Aerius)"}]},"_chembl":{"chemblId":"CHEMBL1172","moleculeType":"Small molecule","molecularWeight":"310.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Grazax works through allergen immunotherapy by gradually exposing the patient to increasing doses of grass pollen extract under the tongue, inducing immune tolerance and reducing allergic responses. Aerius is a selective H1-receptor antagonist that provides symptomatic relief by blocking histamine-mediated allergic reactions. The combination addresses both the underlying immune dysregulation and acute allergic symptoms.","oneSentence":"Grazax is a sublingual immunotherapy tablet that desensitizes the immune system to grass pollen allergens, while Aerius (desloratadine) is an antihistamine that blocks histamine receptors to reduce allergic symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:47:25.998Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Grass pollen-induced allergic rhinitis and/or allergic asthma"}]},"trialDetails":[{"nctId":"NCT01740284","phase":"PHASE3","title":"A Trial Evaluating Tolerability of Grazax Treatment in Combination With Antihistamine","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2008-09","conditions":"Allergic Rhinoconjunctivitis","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Grazax + Aerius","genericName":"Grazax + Aerius","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Grazax is a treatment for seasonal grass pollen-induced allergic rhinoconjunctivitis, and it is used in combination with Aerius, a histamine H1 receptor antagonist. Aerius is a small molecule that works by blocking the histamine H1 receptor.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}