{"id":"granisetron-group-g","safety":{"commonSideEffects":[{"rate":"3-14%","effect":"Headache"},{"rate":"3-18%","effect":"Constipation"},{"rate":"2-5%","effect":"Asthenia/fatigue"},{"rate":"2-4%","effect":"Diarrhea"},{"rate":"1-3%","effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL1237080","moleculeType":"Small molecule","molecularWeight":"348.88"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Granisetron works by competitively blocking 5-HT3 receptors on vagal afferent nerves in the gastrointestinal tract and in the chemoreceptor trigger zone of the brain. By preventing serotonin from binding to these receptors, it suppresses the signals that trigger the vomiting reflex, making it highly effective for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).","oneSentence":"Granisetron is a selective serotonin 5-HT3 receptor antagonist that blocks nausea and vomiting signals in the chemoreceptor trigger zone and gastrointestinal tract.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:57.468Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV)"},{"name":"Postoperative nausea and vomiting (PONV)"},{"name":"Radiation-induced nausea and vomiting"}]},"trialDetails":[{"nctId":"NCT06540885","phase":"PHASE4","title":"A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery","status":"RECRUITING","sponsor":"University of Malaya","startDate":"2025-01-06","conditions":"Postoperative Nausea and Vomiting, Scoliosis","enrollment":74},{"nctId":"NCT06031090","phase":"PHASE2","title":"Clonidine Versus Granisetron for Shivering Prevension","status":"UNKNOWN","sponsor":"Zagazig University","startDate":"2023-03-05","conditions":"Post Spinal Anesthesia Shivering","enrollment":186},{"nctId":"NCT05314257","phase":"PHASE2, PHASE3","title":"Role of Granisetron in Preventing Hypotension After Spinal Anesthesia With Levobupivacaine in Rheumatic Patients Undergoing Elective Cesarean Section","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2022-04","conditions":"Granisetron","enrollment":102},{"nctId":"NCT04836819","phase":"NA","title":"Analgesia Management in Bariatric Surgery","status":"COMPLETED","sponsor":"Ondokuz Mayıs University","startDate":"2021-04-08","conditions":"Morbid Obesity, Bariatric Surgery Candidate, Pain","enrollment":78},{"nctId":"NCT04899817","phase":"PHASE4","title":"Granisteron Versus Metoclopramide in Laparoscopic Cholecystectomy","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2021-05","conditions":"Nausea and Vomiting, Postoperative","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":29,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["antiemetic"],"phase":"marketed","status":"active","brandName":"Granisetron (Group G)","genericName":"Granisetron (Group G)","companyName":"University of Malaya","companyId":"university-of-malaya","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Granisetron is a selective serotonin 5-HT3 receptor antagonist that blocks nausea and vomiting signals in the chemoreceptor trigger zone and gastrointestinal tract. Used for Chemotherapy-induced nausea and vomiting (CINV), Postoperative nausea and vomiting (PONV), Radiation-induced nausea and vomiting.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}