{"id":"gp2411","safety":{"commonSideEffects":[{"rate":null,"effect":"Bone pain"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"GP2411 is a granulocyte colony-stimulating factor (G-CSF) biosimilar designed to mimic the action of filgrastim by binding to G-CSF receptors on hematopoietic progenitor cells. This stimulates proliferation, differentiation, and activation of neutrophil precursors, increasing circulating neutrophil counts. It is used to prevent or reduce the severity of neutropenia in patients undergoing chemotherapy or other myelosuppressive treatments.","oneSentence":"GP2411 is a biosimilar of filgrastim that stimulates the production and release of neutrophils from bone marrow to support immune function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:17.152Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of chemotherapy-induced neutropenia (febrile neutropenia prophylaxis)"},{"name":"Mobilization of peripheral blood progenitor cells for autologous stem cell transplantation"}]},"trialDetails":[{"nctId":"NCT03974100","phase":"PHASE3","title":"Study Investigating PK, PD, Efficacy, Safety, and Immunogenicity of Biosimilar Denosumab (GP2411) in Patients With Postmenopausal Osteoporosis","status":"COMPLETED","sponsor":"Sandoz","startDate":"2019-07-02","conditions":"Postmenopausal Women With Osteoporosis","enrollment":527}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"GP2411","genericName":"GP2411","companyName":"Sandoz","companyId":"sandoz","modality":"Biologic","firstApprovalDate":"","aiSummary":"GP2411 is a biosimilar of filgrastim that stimulates the production and release of neutrophils from bone marrow to support immune function. Used for Prevention of chemotherapy-induced neutropenia (febrile neutropenia prophylaxis), Mobilization of peripheral blood progenitor cells for autologous stem cell transplantation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}