{"id":"gonadotopin-hmg","safety":{"commonSideEffects":[{"rate":"1-10%","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":"5-15%","effect":"Headache"},{"rate":"5-10%","effect":"Injection site reactions"},{"rate":"10-20%","effect":"Abdominal pain and bloating"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-30%","effect":"Multiple pregnancy"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HMG is a purified extract of gonadotropins derived from the urine of postmenopausal women, containing both FSH and LH activity. It binds to FSH and LH receptors on ovarian follicles, promoting follicular growth and maturation. This leads to increased estrogen production and multiple ovulation, making it essential for assisted reproductive technologies.","oneSentence":"HMG (human menopausal gonadotropin) stimulates the ovaries to produce multiple eggs by mimicking follicle-stimulating hormone (FSH) and luteinizing hormone (LH).","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:17.738Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anovulation and infertility in women undergoing assisted reproductive technology (ART)"},{"name":"Ovulation induction in women with polycystic ovary syndrome (PCOS)"},{"name":"Male hypogonadism and infertility"}]},"trialDetails":[{"nctId":"NCT00830492","phase":"PHASE4","title":"Clomiphene Citrate (CC)/Gonadotropin/Gonadotropin Releasing Hormone (GnRH) Antagonist Versus Gonadotropin/GnRH Agonist","status":"COMPLETED","sponsor":"Yazd Research & Clinical Center for Infertility","startDate":"2008-01","conditions":"Ovarian Stimulation","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"gonadotopin (HMG)","genericName":"gonadotopin (HMG)","companyName":"Yazd Research & Clinical Center for Infertility","companyId":"yazd-research-clinical-center-for-infertility","modality":"Small molecule","firstApprovalDate":"","aiSummary":"HMG (human menopausal gonadotropin) stimulates the ovaries to produce multiple eggs by mimicking follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Used for Anovulation and infertility in women undergoing assisted reproductive technology (ART), Ovulation induction in women with polycystic ovary syndrome (PCOS), Male hypogonadism and infertility.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}