{"id":"gnrh-agonist-trigger","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Abdominal discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"GnRH agonists bind to GnRH receptors on pituitary gonadotroph cells, causing an initial surge in gonadotropin release. This LH surge triggers the resumption of meiosis I in oocytes and weakening of follicular attachments, leading to ovulation. In ART protocols, the agonist is used after pituitary downregulation to provide a physiologic trigger for final egg maturation and retrieval timing.","oneSentence":"GnRH agonist trigger induces a surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to trigger final oocyte maturation and ovulation in assisted reproductive technology cycles.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:31:31.062Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Final oocyte maturation trigger in assisted reproductive technology (ART) cycles"},{"name":"Ovulation induction in controlled ovarian hyperstimulation protocols"}]},"trialDetails":[{"nctId":"NCT07269392","phase":"PHASE4","title":"Dual Trigger With HCG and GnRH Agonist on Thawed Modified Natural Cycle Embryo Transfer","status":"NOT_YET_RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2026-01-01","conditions":"In Vitro Fertilization (IVF), Embryo 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Used for Final oocyte maturation trigger in assisted reproductive technology (ART) cycles, Ovulation induction in controlled ovarian hyperstimulation protocols.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}