{"id":"gnrh-agonist-lupron-depot","safety":{"commonSideEffects":[{"rate":"60-80","effect":"Hot flashes"},{"rate":"10-20","effect":"Injection site reaction"},{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Mood changes/depression"},{"rate":"40-60","effect":"Decreased libido"},{"rate":"30-50","effect":"Erectile dysfunction"},{"rate":null,"effect":"Bone density loss"}]},"_chembl":{"chemblId":"CHEMBL442806","moleculeType":"Small molecule","molecularWeight":"1300.49"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"GnRH agonists work by initially stimulating the pituitary gland's GnRH receptors, causing a brief surge in LH and FSH. With continuous exposure, this leads to receptor desensitization and downregulation, resulting in sustained suppression of gonadotropins and consequent reduction in testosterone (in males) or estrogen (in females). This hormonal suppression is therapeutically exploited in conditions where sex hormone reduction is beneficial.","oneSentence":"Lupron Depot is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:14:08.643Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Central precocious puberty"},{"name":"Prostate cancer (advanced)"},{"name":"Endometriosis"},{"name":"Uterine fibroids"}]},"trialDetails":[{"nctId":"NCT07027124","phase":"PHASE2","title":"Neoadjuvant ADT + Darolutamide With Pembrolizumab, Followed by Adjuvant Pembrolizumab in Molecularly Stratified High-Risk Prostate Cancer","status":"RECRUITING","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2026-03-19","conditions":"Prostate Cancer, High-risk Prostate Cancer","enrollment":40},{"nctId":"NCT04557059","phase":"PHASE3","title":"A Study of Adding 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