{"id":"gnrh-agonist-1500e-hcg","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Mood changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"GnRH agonists initially stimulate the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which then act on the gonads. The addition of exogenous hCG (human chorionic gonadotropin) provides supplemental LH-like activity to further stimulate testosterone or estrogen production. This combination is typically used in fertility treatment to support ovulation induction or spermatogenesis.","oneSentence":"A GnRH agonist combined with hCG that stimulates the pituitary-gonadal axis to increase gonadotropin secretion and sex hormone production.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:33:04.653Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ovulation induction in assisted reproductive technology (ART)"},{"name":"Male infertility due to hypogonadism"}]},"trialDetails":[{"nctId":"NCT01683513","phase":"PHASE4","title":"Trial Comparing hCG Triggering Versus GnRH Agonist Triggering in PCOS Patients","status":"COMPLETED","sponsor":"AZ Jan Palfijn Gent","startDate":"2011-11","conditions":"Infertility, PCOS","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"GnRh agonist +1500E hCG","genericName":"GnRh agonist +1500E hCG","companyName":"AZ Jan Palfijn Gent","companyId":"az-jan-palfijn-gent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A GnRH agonist combined with hCG that stimulates the pituitary-gonadal axis to increase gonadotropin secretion and sex hormone production. Used for Ovulation induction in assisted reproductive technology (ART), Male infertility due to hypogonadism.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}