{"id":"glymidine","rwe":[{"pmid":"9342417","year":"1997","title":"Evaluation of phototoxic properties of oral antidiabetics and diuretics. Photohemolysis model as a screening method for recognizing potential photosensitizing drugs.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"9134756","year":"1997","title":"Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics.","finding":"","journal":"Journal of photochemistry and photobiology. B, Biology","studyType":"Clinical Study"},{"pmid":"9361121","year":"1997","title":"Phototoxicity to sulphonamide-derived oral antidiabetics and diuretics: investigations in hairless mice.","finding":"","journal":"Photodermatology, photoimmunology & photomedicine","studyType":"Clinical Study"},{"pmid":"9067780","year":"1997","title":"Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations.","finding":"","journal":"In vivo (Athens, Greece)","studyType":"Clinical Study"},{"pmid":"9037453","year":"1997","title":"Studies on the phototoxic effects of oral antidiabetics and diuretics.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"}],"tags":[{"label":"glymidine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A10BC01","category":"atc"},{"label":"Active","category":"status"},{"label":"Diabetes mellitus type 2","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"gondafon","offLabel":[],"synonyms":["glidiazine","glycodiazine","glymidine","glycodiazine sodium","glymidine sodium","gondafon"],"timeline":[],"approvals":[],"brandName":"Gondafon","ecosystem":[{"indication":"Diabetes mellitus type 2","otherDrugs":[{"name":"acarbose","slug":"acarbose","company":"Bayer Hlthcare"},{"name":"acetohexamide","slug":"acetohexamide","company":"Lilly"},{"name":"albiglutide","slug":"albiglutide","company":"Glaxosmithkline Llc"},{"name":"alogliptin","slug":"alogliptin","company":"Takeda Pharms Usa"}],"globalPrevalence":537000000}],"mechanism":{"modality":"Small Molecule","drugClass":"glymidine","explanation":"In simple terms, Gondafon helps the body produce more insulin, a hormone that regulates blood sugar levels. This can help lower blood sugar levels in people with type 2 diabetes. By improving insulin production, Gondafon can help manage the symptoms of diabetes.","oneSentence":"Gondafon works by stimulating insulin release from the pancreas.","technicalDetail":"Gondafon is a glymidine, a class of compounds that act as insulin secretagogues, stimulating the release of insulin from the pancreatic beta cells through a mechanism involving the closure of ATP-sensitive potassium channels and depolarization of the cell membrane."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1321","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=GLYMIDINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=GLYMIDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:47:33.545090","biosimilars":[],"competitors":[],"genericName":"glymidine","indications":{"approved":[{"name":"Diabetes mellitus type 2","source":"DrugCentral","snomedId":44054006,"regulator":"FDA","usPrevalence":37300000,"globalPrevalence":537000000,"prevalenceMethod":"curated","prevalenceSource":"IDF Diabetes Atlas, 2024"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT02476760","phase":"","title":"Incretin-based Drugs and Acute Pancreatitis","status":"COMPLETED","sponsor":"Canadian Network for Observational Drug Effect Studies, CNODES","startDate":"2014-03","conditions":["Diabetes Mellitus, Type 2"],"enrollment":1417914,"completionDate":"2015-04"},{"nctId":"NCT02456428","phase":"","title":"Incretin-based Drugs and the Risk of Heart Failure","status":"COMPLETED","sponsor":"Canadian Network for Observational Drug Effect Studies, CNODES","startDate":"2014-03","conditions":["Type 2 Diabetes Mellitus"],"enrollment":1499650,"completionDate":"2015-05"},{"nctId":"NCT02475499","phase":"","title":"Incretin-based Drugs and Pancreatic Cancer","status":"COMPLETED","sponsor":"Canadian Network for Observational Drug Effect Studies, CNODES","startDate":"2014-03","conditions":["Diabetes Mellitus, Type 2"],"enrollment":886172,"completionDate":"2015-04"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"4C5I4BQZ8F","CHEBI":"CHEBI:146188","INN_ID":"1804","RXNORM":"102848","UMLSCUI":"C0351000","ChEMBL_ID":"CHEMBL1697838","KEGG_DRUG":"D01356","DRUGBANK_ID":"DB01382","PUBCHEM_CID":"9565","SNOMEDCT_US":"325252003","SECONDARY_CAS_RN":"339-44-6","MESH_SUPPLEMENTAL_RECORD_UI":"C073263"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":23,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"A10BC01","allCodes":["A10BC01"]},"biosimilarFilings":[],"recentPublications":[{"date":"1997 Sep","pmid":"9342417","title":"Evaluation of phototoxic properties of oral antidiabetics and diuretics. Photohemolysis model as a screening method for recognizing potential photosensitizing drugs.","journal":"Arzneimittel-Forschung"},{"date":"1997 Mar","pmid":"9134756","title":"Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics.","journal":"Journal of photochemistry and photobiology. B, Biology"},{"date":"1997 Feb-Apr","pmid":"9361121","title":"Phototoxicity to sulphonamide-derived oral antidiabetics and diuretics: investigations in hairless mice.","journal":"Photodermatology, photoimmunology & photomedicine"},{"date":"1997 Jan-Feb","pmid":"9067780","title":"Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations.","journal":"In vivo (Athens, Greece)"},{"date":"1997 Jan","pmid":"9037453","title":"Studies on the phototoxic effects of oral antidiabetics and diuretics.","journal":"Arzneimittel-Forschung"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gondafon is a small molecule with the synonyms GLIDIAZINE, GLYCODIAZINE, GLYMIDINE, GLYMIDINE, GONDAFON, and REDUL. It has been studied in clinical trials for the treatment of Type 2 Diabetes Mellitus, specifically in combination with DPP-4 inhibitors, GLP-1 analogs, and Sulfonylureas.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}