{"id":"glycoprotein-iib-iiia-inhibitors","safety":{"commonSideEffects":[{"rate":"1-2","effect":"Thrombocytopenia"},{"rate":"5-15","effect":"Bleeding"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"These agents competitively inhibit the glycoprotein IIb/IIIa receptor on the platelet surface, which is the final step in platelet aggregation regardless of the initial stimulus. By blocking fibrinogen and other adhesive molecules from cross-linking platelets, they prevent thrombus formation. This class is used primarily in acute coronary syndromes to reduce ischemic complications during percutaneous coronary intervention.","oneSentence":"Glycoprotein IIb/IIIa inhibitors block the final common pathway of platelet aggregation by preventing fibrinogen binding to activated platelets.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:31:23.657Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Glycoprotein_IIb%2FIIIa_inhibitors","title":"Glycoprotein IIb/IIIa inhibitors","extract":"In medicine, glycoprotein IIb/IIIa inhibitors, also GpIIb/IIIa inhibitors, is a class of antiplatelet agents."},"indications":{"approved":[{"name":"Acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction)"},{"name":"Percutaneous coronary intervention in patients at high risk for ischemic complications"}]},"trialDetails":[{"nctId":"NCT05193019","phase":"","title":"Parenteral Antiplatelet Agents in Real-world Spanish PCI Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fundación EPIC","startDate":"2022-03-14","conditions":"Ischemic Heart Disease, Acute Coronary Syndrome","enrollment":717},{"nctId":"NCT02739711","phase":"PHASE4","title":"Glycoprotein IIb/IIIa Inhibitors Versus Standard Therapy in Patients with Myocardial Infarction and No-reflow","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Luebeck","startDate":"2016-07","conditions":"Acute Myocardial Infarction","enrollment":120},{"nctId":"NCT05098977","phase":"","title":"The Usefulness of Assessing Heart Rate Variability in Patients With Acute Myocardial Infarction","status":"UNKNOWN","sponsor":"Grigore T. 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Used for Acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction), Percutaneous coronary intervention in patients at high risk for ischemic complications.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}