{"id":"glycobiarsol","rwe":[{"pmid":"5389346","year":"1969","title":"Glycobiarsol for the control of Trichuris vulpis infection in the dog.","finding":"","journal":"Australian veterinary journal","studyType":"Clinical Study"},{"pmid":"13967608","year":"1963","title":"Treatment of Trichuris vulpis infection of dogs with glycobiarsol.","finding":"","journal":"American journal of veterinary research","studyType":"Clinical Study"},{"pmid":"14023142","year":"1962","title":"[On the treatment of trichuriasis with glycobiarsol].","finding":"","journal":"Hospital (Rio de Janeiro, Brazil)","studyType":"Clinical Study"},{"pmid":"14485229","year":"1962","title":"[Trichuriasis, General considerations. (Trichurotic?) hemorrhagic typhlitis. Therapy with glycobiarsol].","finding":"","journal":"Hospital (Rio de Janeiro, Brazil)","studyType":"Clinical Study"},{"pmid":"13900050","year":"1962","title":"[Treatment of trichocephaliasis with glycobiarsol].","finding":"","journal":"Hospital (Rio de Janeiro, Brazil)","studyType":"Clinical Study"}],"tags":[{"label":"glycobiarsol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"P01AR03","category":"atc"},{"label":"Active","category":"status"},{"label":"Acute amebiasis","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"milibis","offLabel":[],"synonyms":["glycobiarsol","bismuth glycollylarsanilate","milibis"],"timeline":[],"approvals":[],"brandName":"Milibis","ecosystem":[{"indication":"Acute amebiasis","otherDrugs":[{"name":"metronidazole","slug":"metronidazole","company":"Gd Searle Llc"},{"name":"paromomycin","slug":"paromomycin","company":""},{"name":"tinidazole","slug":"tinidazole","company":"Mission Pharma"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"glycobiarsol","explanation":"In simple terms, Milibis stops the amoeba from multiplying and causing harm in the body. This allows the body's natural defenses to fight off the infection and recover. By targeting the parasite directly, Milibis helps to alleviate symptoms and prevent complications.","oneSentence":"Milibis works by inhibiting the growth and replication of the amoeba Entamoeba histolytica.","technicalDetail":"Milibis is a glycobiarsol that exerts its antiparasitic effects by interfering with the synthesis of glycoconjugates in the amoeba, ultimately leading to cell death and inhibition of parasite replication."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4849","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=GLYCOBIARSOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:47:00.846624","biosimilars":[],"competitors":[],"genericName":"glycobiarsol","indications":{"approved":[{"name":"Acute amebiasis","source":"DrugCentral","snomedId":39224005,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002951","UNII":"E3U8347QWJ","CHEBI":"CHEBI:136035","INN_ID":"16","UMLSCUI":"C0301343","ChEMBL_ID":"CHEMBL1788392","KEGG_DRUG":"D07358","PUBCHEM_CID":"16682839","SNOMEDCT_US":"86955008"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"P01AR03","allCodes":["P01AR03","P01AR53"]},"biosimilarFilings":[],"recentPublications":[{"date":"1969 Aug","pmid":"5389346","title":"Glycobiarsol for the control of Trichuris vulpis infection in the dog.","journal":"Australian veterinary journal"},{"date":"1963 Jul","pmid":"13967608","title":"Treatment of Trichuris vulpis infection of dogs with glycobiarsol.","journal":"American journal of veterinary research"},{"date":"1962 Dec","pmid":"14023142","title":"[On the treatment of trichuriasis with glycobiarsol].","journal":"Hospital (Rio de Janeiro, Brazil)"},{"date":"1962 Jan","pmid":"14485229","title":"[Trichuriasis, General considerations. (Trichurotic?) hemorrhagic typhlitis. Therapy with glycobiarsol].","journal":"Hospital (Rio de Janeiro, Brazil)"},{"date":"1962 Jan","pmid":"13900050","title":"[Treatment of trichocephaliasis with glycobiarsol].","journal":"Hospital (Rio de Janeiro, Brazil)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Milibis, also known as GlycoBIARSOL, is a small molecule drug in the glycobiarsol class. It is used to treat acute amebiasis, a parasitic infection caused by the amoeba Entamoeba histolytica. The commercial status of Milibis is unclear, and it is not known whether it is patented or available as a generic. Further information on its pharmacokinetics and safety profile is also lacking. As a result, its use should be approached with caution and under the guidance of a qualified healthcare professional.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}