{"id":"glycerylphosphorylcholine","rwe":[{"pmid":"41344038","year":"2026","title":"Multi-functional zwitterionic glycerylphosphorylcholine hydrogel for human motion detection and human-machine interaction.","finding":"","journal":"Journal of colloid and interface science","studyType":"Clinical Study"},{"pmid":"41130985","year":"2025","title":"Synergistic Interface Modification of Electron-Beam-Evaporated NiO(x) for High-Performance Perovskite Solar Cells.","finding":"","journal":"ACS applied materials & interfaces","studyType":"Clinical Study"},{"pmid":"40883125","year":"2025","title":"Lowering plasma S-Adenosylhomocysteine (SAH) in healthy adults with elevated SAH and normal homocysteine using nutritional supplementation.","finding":"","journal":"Nutrition, metabolism, and cardiovascular diseases : NMCD","studyType":"Clinical Study"},{"pmid":"40556032","year":"2025","title":"L-Alpha-Glycerylphosphorylcholine (L-α-GPC): A Comprehensive Review of Its Preparation Techniques and Versatile Biological Effects.","finding":"","journal":"Journal of food science","studyType":"Clinical Study"},{"pmid":"40243143","year":"2025","title":"Strong Dipole Inner Salt Molecule as Interface Ion Bridge for Rechargeable Aqueous Zn-Anode Batteries.","finding":"","journal":"The journal of physical chemistry letters","studyType":"Clinical Study"}],"tags":[{"label":"glycerylphosphorylcholine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"glycerophosphocholine","offLabel":[],"synonyms":["glycerol phosphorylcholine","glycerophosphocholine","glycerophosphoric acid choline ester","glycerophosphorylcholine","glycerylphosphocholine","glycerylphosphorylcholine"],"timeline":[],"approvals":[],"brandName":"Glycerophosphocholine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"glycerylphosphorylcholine","explanation":"Imagine your brain's neurons as a busy city with many messengers running around. Acetylcholine is one of these messengers that helps keep the city running smoothly. Glycerophosphocholine is thought to help increase the production of acetylcholine, which can help protect the city from damage and keep it running efficiently.","oneSentence":"Glycerophosphocholine is thought to work by increasing the levels of a neurotransmitter called acetylcholine in the brain, which helps to protect neurons from damage.","technicalDetail":"Glycerophosphocholine is believed to exert its effects by increasing the activity of the enzyme choline acetyltransferase, which is responsible for producing acetylcholine from its precursor choline."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3906","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=glycerylphosphorylcholine","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=glycerylphosphorylcholine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:46:54.764243","biosimilars":[],"competitors":[],"genericName":"glycerylphosphorylcholine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07495592","phase":"NA","title":"The Acute Effects of Onnit Alpha Brain on Cognition and Mood States","status":"NOT_YET_RECRUITING","sponsor":"Applied Science & Performance Institute","startDate":"2026-04-16","conditions":["Cognitive","Mood and Cognitive Performance","Sleep Deprivation"],"enrollment":34,"completionDate":"2026-08-15"},{"nctId":"NCT07397273","phase":"NA","title":"Acute Effects of Alpha-glycerylphosphorylcholine (A-GPC) on Lower Body Muscular Performance.","status":"NOT_YET_RECRUITING","sponsor":"Northern Illinois University","startDate":"2026-03-16","conditions":["Healthy Adult Participants"],"enrollment":20,"completionDate":"2026-05-16"},{"nctId":"NCT02168738","phase":"NA","title":"Investigation of Docosahexaenoic Acid (DHA) Metabolic Pathway in Human by Using 13C Labeled Molecules","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2014-03","conditions":["Healthy Subject"],"enrollment":4,"completionDate":"2015-04"},{"nctId":"NCT07267845","phase":"NA","title":"The Effect of α-GPC on Cognitive Function and Sports Performance","status":"RECRUITING","sponsor":"Nanjing Nutrabuilding Bio-tech Co., Ltd.","startDate":"2025-10-21","conditions":["Healthy Participants"],"enrollment":80,"completionDate":"2026-07-05"},{"nctId":"NCT06758661","phase":"PHASE1","title":"Clinical Study to Evaluate Drug-drug Interaction and Safety After Co-administration of D352 and D794 in Healthy Adult Volunteers","status":"COMPLETED","sponsor":"Chong Kun Dang Pharmaceutical","startDate":"2024-11-27","conditions":["Dyslipidemia"],"enrollment":40,"completionDate":"2025-02-03"},{"nctId":"NCT05383183","phase":"PHASE4","title":"Efficacy and Safety of ChOline ALfoscerate in Patient With Mild to Moderate Alzheimer's Disease","status":"RECRUITING","sponsor":"Daewoong Bio Inc.","startDate":"2022-01-20","conditions":["Alzheimer Disease"],"enrollment":630,"completionDate":"2025-12-09"},{"nctId":"NCT04785144","phase":"PHASE1","title":"Safety and Immunogenicity Study of a SARS-CoV-2 (COVID-19) Variant Vaccine (mRNA-1273.351) in Naïve and Previously Vaccinated Adults","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2021-03-31","conditions":["COVID-19","COVID-19 Immunisation"],"enrollment":135,"completionDate":"2022-07-05"},{"nctId":"NCT05084989","phase":"PHASE2","title":"Safety, and Immunogenicity Study of the Recombinant Two-component COVID-19 Vaccine (CHO Cell)","status":"COMPLETED","sponsor":"Jiangsu Rec-Biotechnology Co., Ltd.","startDate":"2022-01-31","conditions":["COVID-19"],"enrollment":948,"completionDate":"2023-02-09"},{"nctId":"NCT05366296","phase":"PHASE1","title":"Safety, Reactogenicity, and Immunogenicity Study of a Lyophilized COVID-19 mRNA Vaccine","status":"WITHDRAWN","sponsor":"Wuhan Recogen Biotechnology Co., Ltd.","startDate":"2022-07","conditions":["COVID-19 Pandemic"],"enrollment":0,"completionDate":"2023-01"},{"nctId":"NCT04733833","phase":"PHASE2","title":"A Study to Evaluate the Efficacy and Safety of VB-201 in Patients With COVID-19","status":"COMPLETED","sponsor":"Vascular Biogenics Ltd. operating as VBL Therapeutics","startDate":"2021-01-26","conditions":["Severe COVID-19"],"enrollment":5,"completionDate":"2022-10-25"},{"nctId":"NCT04939311","phase":"PHASE1,PHASE2","title":"Immunomodulation Using VB-201 to Reduce Arterial Inflammation in Treated HIV - 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Its exact mechanism of action and target are unknown, but it is believed to have neuroprotective properties. The commercial status of glycerophosphocholine is unclear, and it is not FDA-approved for any indications. Further research is needed to fully understand its safety and efficacy. As a result, it is not widely available or prescribed.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}