{"id":"glycerol-oba","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Rebound intracranial pressure elevation"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glycerol is a small polyol that creates an osmotic gradient, pulling water from tissues into the vascular space and reducing brain edema. It is metabolized slowly, allowing sustained osmotic effect. The drug is used primarily to manage elevated intracranial pressure in acute neurological conditions.","oneSentence":"Glycerol acts as an osmotic agent that draws fluid into the intracellular and extracellular spaces, reducing intracranial pressure and edema.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:14:09.163Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Elevated intracranial pressure"},{"name":"Cerebral edema"}]},"trialDetails":[{"nctId":"NCT04087421","phase":"PHASE3","title":"Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome","status":"RECRUITING","sponsor":"University of Aarhus","startDate":"2019-09-17","conditions":"Low Anterior Resection Syndrome, Rectal Cancer","enrollment":114}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Glycerol \"OBA\"","genericName":"Glycerol \"OBA\"","companyName":"University of Aarhus","companyId":"university-of-aarhus","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Glycerol acts as an osmotic agent that draws fluid into the intracellular and extracellular spaces, reducing intracranial pressure and edema. Used for Elevated intracranial pressure, Cerebral edema.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}