{"id":"glycerol-and-paracetamol","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (from glycerol)"},{"rate":null,"effect":"Hepatotoxicity (paracetamol at high doses)"},{"rate":null,"effect":"Rash or hypersensitivity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a combination product where glycerol acts as an osmotic agent and humectant to maintain hydration and potentially improve mucosal function, while paracetamol (acetaminophen) inhibits prostaglandin synthesis to reduce fever and mild-to-moderate pain. The combination appears designed for symptomatic relief in conditions where both hydration support and analgesic/antipyretic effects are beneficial.","oneSentence":"Glycerol provides osmotic hydration and paracetamol reduces fever and pain through cyclooxygenase inhibition.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:14:10.155Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Symptomatic relief of fever and pain (specific indication unclear from available information)"}]},"trialDetails":[{"nctId":"NCT01453842","phase":"EARLY_PHASE1","title":"Diet Oil Induced Stimulation of GLP-1","status":"COMPLETED","sponsor":"University of Copenhagen","startDate":"2011-03","conditions":"Type 2 Diabetes Mellitus","enrollment":12},{"nctId":"NCT00619203","phase":"PHASE3","title":"Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis","status":"COMPLETED","sponsor":"Kamuzu University of Health Sciences","startDate":"2008-03","conditions":"Bacterial Meningitis","enrollment":466}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Glycerol and paracetamol","genericName":"Glycerol and paracetamol","companyName":"Kamuzu University of Health Sciences","companyId":"kamuzu-university-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Glycerol provides osmotic hydration and paracetamol reduces fever and pain through cyclooxygenase inhibition. Used for Symptomatic relief of fever and pain (specific indication unclear from available information).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}