{"id":"glutamine-combined-with-thalidomide","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Neutropenia"},{"rate":"5-15%","effect":"Thrombocytopenia"},{"rate":"10-30%","effect":"Fatigue"},{"rate":"20-40%","effect":"Nausea"},{"rate":"10-30%","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL426123","moleculeType":"Small molecule","molecularWeight":"258.23"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Glutamine supplementation has been found to enhance immune function and increase the production of cytokines. Thalidomide, on the other hand, has been shown to inhibit the production of tumor necrosis factor-alpha (TNF-alpha) and other pro-inflammatory cytokines, leading to its anti-inflammatory effects. The combination of glutamine and thalidomide may work synergistically to modulate the immune response and inhibit tumor growth.","oneSentence":"Glutamine has been shown to have immunomodulatory effects, while thalidomide is known for its antiangiogenic and immunomodulatory properties.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:05.561Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Multiple myeloma"}]},"trialDetails":[{"nctId":"NCT06617182","phase":"PHASE2","title":"Efficacy and Safety of Thalidomide Combined With Glutamine in the Treatment of Radiation Intestinal Injury.","status":"RECRUITING","sponsor":"Yongquan Shi","startDate":"2024-09-30","conditions":"Radiation Enteritis","enrollment":150},{"nctId":"NCT06031012","phase":"PHASE3","title":"Glutamine Combined With Thalidomide in Preventing Radiation-induced Oral Mucositis","status":"COMPLETED","sponsor":"Air Force Military Medical University, China","startDate":"2023-09-15","conditions":"Mucositis Oral","enrollment":138}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["GT group"],"phase":"phase_3","status":"active","brandName":"glutamine combined with thalidomide","genericName":"glutamine combined with thalidomide","companyName":"Air Force Military Medical University, China","companyId":"air-force-military-medical-university-china","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Glutamine has been shown to have immunomodulatory effects, while thalidomide is known for its antiangiogenic and immunomodulatory properties. Used for Multiple myeloma.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}