{"id":"glucosamine-sulfate-chondroitin-sulfate-condroflex","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Mild allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL2108922","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glucosamine sulfate serves as a precursor for glycosaminoglycan synthesis, supporting cartilage matrix formation and repair. Chondroitin sulfate inhibits cartilage-degrading enzymes and may reduce inflammatory mediators. Together, these agents aim to slow cartilage loss and potentially promote cartilage regeneration in degenerative joint disease.","oneSentence":"Glucosamine sulfate and chondroitin sulfate work together to provide substrate for cartilage synthesis and reduce cartilage degradation in osteoarthritis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:06.165Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis of the knee"},{"name":"Osteoarthritis of other joints"}]},"trialDetails":[{"nctId":"NCT03936192","phase":"PHASE3","title":"A Parallel-group Active Comparator, Double-blind, Multicenter, Randomized, Double-blind, Phase III Clinical Study","status":"WITHDRAWN","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2019-01","conditions":"Knee Osteoarthritis","enrollment":""},{"nctId":"NCT02830919","phase":"PHASE3","title":"Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee OA (GLACIAL)","status":"COMPLETED","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2016-12-05","conditions":"Osteoarthritis of Knee","enrollment":627},{"nctId":"NCT00860873","phase":"PHASE3","title":"Effectiveness of Glucosamine + Chondroitin in Osteoarthrosis","status":"COMPLETED","sponsor":"Azidus Brasil","startDate":"2009-10","conditions":"Osteoarthrosis","enrollment":280},{"nctId":"NCT01293305","phase":"PHASE3","title":"Study With Chondroitin Sulfate and Glucosamine Sulfate (in Dosage Capsule and Sachet) in Treating Osteoarthritis","status":"UNKNOWN","sponsor":"Azidus Brasil","startDate":"2011-11","conditions":"Osteoarthritis","enrollment":320},{"nctId":"NCT01172249","phase":"PHASE3","title":"Non-inferiority Study of the Glucosamine Sulfate + Chondroitin Sulfate Association Capsule in Comparison to the CONDROFLEX® Product in Osteoarthrosis of the Knee","status":"UNKNOWN","sponsor":"Mantecorp Industria Quimica e Farmaceutica Ltd.","startDate":"","conditions":"Osteoarthritis, Knee","enrollment":250}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Condroflex ®"],"phase":"phase_3","status":"active","brandName":"Glucosamine sulfate + chondroitin sulfate - CONDROFLEX","genericName":"Glucosamine sulfate + chondroitin sulfate - CONDROFLEX","companyName":"Mantecorp Industria Quimica e Farmaceutica Ltd.","companyId":"mantecorp-industria-quimica-e-farmaceutica-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Glucosamine sulfate and chondroitin sulfate work together to provide substrate for cartilage synthesis and reduce cartilage degradation in osteoarthritis. Used for Osteoarthritis of the knee, Osteoarthritis of other joints.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}