{"id":"glatiramer-acetate-gtr","safety":{"commonSideEffects":[{"rate":"90","effect":"Injection site reactions (erythema, induration, pruritus)"},{"rate":"10–15","effect":"Immediate post-injection reaction (flushing, chest tightness, dyspnea, palpitations)"},{"rate":"5–10","effect":"Lipoatrophy at injection sites"},{"rate":"35","effect":"Headache"},{"rate":"20–30","effect":"Infection (upper respiratory, urinary tract)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glatiramer acetate mimics myelin basic protein and acts as a decoy antigen, shifting the immune response from pro-inflammatory Th1/Th17 cells toward anti-inflammatory Th2 and regulatory T cells. This reduces the activation and infiltration of autoreactive lymphocytes into the central nervous system, thereby decreasing demyelination and neuroinflammation in multiple sclerosis.","oneSentence":"Glatiramer acetate is a synthetic polypeptide that modulates immune responses by promoting anti-inflammatory T cell and B cell responses, reducing autoimmune attack on myelin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:13:58.263Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relapsing-remitting multiple sclerosis (RRMS)"},{"name":"Clinically isolated syndrome (CIS) with high risk of MS"}]},"trialDetails":[{"nctId":"NCT01489254","phase":"PHASE3","title":"Efficacy and Safety of GTR in Comparison to Copaxone®","status":"COMPLETED","sponsor":"Synthon BV","startDate":"2011-10","conditions":"Multiple Sclerosis","enrollment":794}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Glatiramer Acetate (GTR)","genericName":"Glatiramer Acetate (GTR)","companyName":"Synthon BV","companyId":"synthon-bv","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Glatiramer acetate is a synthetic polypeptide that modulates immune responses by promoting anti-inflammatory T cell and B cell responses, reducing autoimmune attack on myelin. Used for Relapsing-remitting multiple sclerosis (RRMS), Clinically isolated syndrome (CIS) with high risk of MS.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}