{"id":"glargine-u300","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Lipodystrophy"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glargine U300 is an ultra-long-acting insulin analog derived from insulin glargine, formulated at a higher concentration (300 units/mL) to provide an extended duration of action of up to 36 hours or more. It mimics endogenous insulin by activating insulin receptors on muscle and adipose tissue to facilitate glucose uptake, and simultaneously inhibits gluconeogenesis and glycogenolysis in the liver. This sustained basal insulin coverage helps maintain glycemic control throughout the day and night in patients with diabetes.","oneSentence":"Glargine U300 is a long-acting basal insulin that binds to insulin receptors to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:31:17.649Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus"},{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT07173712","phase":"PHASE4","title":"Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Yanbing Li","startDate":"2026-03-15","conditions":"Type 2 Diabetes","enrollment":324},{"nctId":"NCT05002933","phase":"PHASE4","title":"A Clinical Efficacy and Safety Study of Insulin Glargine U300 in Chinese Adult Patients With Uncontrolled Type 2 Diabetes Mellitus 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