{"id":"gk567","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Gastrointestinal disorders"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glucokinase activators work by increasing the catalytic activity of glucokinase, an enzyme that acts as a glucose sensor in pancreatic beta cells. By enhancing glucokinase activity, GK567 lowers the glucose threshold needed to trigger insulin secretion, thereby improving glycemic control in a glucose-dependent manner. This mechanism is intended to reduce hypoglycemia risk compared to other insulin secretagogues.","oneSentence":"GK567 is a glucokinase activator that enhances glucose metabolism in pancreatic beta cells to stimulate insulin secretion.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:14:02.131Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT01541930","phase":"PHASE3","title":"An Open, Uncontrolled Study of GK567 in the Deodorization of Malodorous Fungating Neoplastic Tumours","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2012-04","conditions":"Malodorous Infected Cutaneous Ulcer","enrollment":21}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["GK567: Metronidazole Gel 0.75%"],"phase":"phase_3","status":"active","brandName":"GK567","genericName":"GK567","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"GK567 is a glucokinase activator that enhances glucose metabolism in pancreatic beta cells to stimulate insulin secretion. Used for Type 2 diabetes mellitus.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}