{"id":"gitoxin","rwe":[{"pmid":"41471836","year":"2025","title":"Rotation Conformational Effects of Selected Cytotoxic Cardiac Glycosides on Their Interactions with Na(+)/K(+)-ATPase.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"37555372","year":"2023","title":"A Short Route to the Synthesis of Digoxose Trisaccharide Glycal Donor via Mislow-Evans Rearrangement.","finding":"","journal":"The Journal of organic chemistry","studyType":"Clinical Study"},{"pmid":"37397486","year":"2023","title":"Lanatoside C decelerates proliferation and induces apoptosis through inhibition of STAT3 and ROS-mediated mitochondrial membrane potential transformation in cholangiocarcinoma.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"33794459","year":"2021","title":"Virtual screening of plant-derived compounds against SARS-CoV-2 viral proteins using computational tools.","finding":"","journal":"The Science of the total environment","studyType":"Clinical Study"},{"pmid":"33331728","year":"2020","title":"[A poisonous spring smoothie with wild herbs: accidental intoxication with foxglove (Digitalis purpurea)].","finding":"","journal":"Nederlands tijdschrift voor geneeskunde","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bigitalin","offLabel":[],"synonyms":["gitoxin","anhydrogitalin","bigitalin","pseudodigitoxin"],"timeline":[],"approvals":[],"brandName":"Bigitalin","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your heart is like a orchestra, and gitoxin is like a conductor that helps the different parts of the heart work together in sync. It does this by affecting the electrical signals that control the heartbeat, helping to prevent irregular rhythms. This can be especially important for people with conditions like atrial fibrillation.","oneSentence":"Gitoxin works by interacting with cardiac ion channels to regulate heart rhythm.","technicalDetail":"Gitoxin is a cardiac glycoside that inhibits the sodium-potassium ATPase pump, leading to increased intracellular sodium and calcium levels, which in turn enhances the contractility of cardiac muscle and slows the heart rate."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3262","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=gitoxin","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:45:02.809322","biosimilars":[],"competitors":[],"genericName":"gitoxin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"VOR2TD6SO4","CHEBI":"CHEBI:28503","UMLSCUI":"C0061285","ChEMBL_ID":"CHEMBL109317","PUBCHEM_CID":"91540","MESH_SUPPLEMENTAL_RECORD_UI":"C005003"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec 18","pmid":"41471836","title":"Rotation Conformational Effects of Selected Cytotoxic Cardiac Glycosides on Their Interactions with Na(+)/K(+)-ATPase.","journal":"Molecules (Basel, Switzerland)"},{"date":"2023 Aug 18","pmid":"37555372","title":"A Short Route to the Synthesis of Digoxose Trisaccharide Glycal Donor via Mislow-Evans Rearrangement.","journal":"The Journal of organic chemistry"},{"date":"2023","pmid":"37397486","title":"Lanatoside C decelerates proliferation and induces apoptosis through inhibition of STAT3 and ROS-mediated mitochondrial membrane potential transformation in cholangiocarcinoma.","journal":"Frontiers in pharmacology"},{"date":"2021 Aug 10","pmid":"33794459","title":"Virtual screening of plant-derived compounds against SARS-CoV-2 viral proteins using computational tools.","journal":"The Science of the total environment"},{"date":"2020 Nov 12","pmid":"33331728","title":"[A poisonous spring smoothie with wild herbs: accidental intoxication with foxglove (Digitalis purpurea)].","journal":"Nederlands tijdschrift voor geneeskunde"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Gitoxin, also known as Bigitalin, is a small molecule medication with unknown drug class and target. It is not FDA approved for any indications. The commercial status of gitoxin is unclear, and it is not known whether it is patented or available as a generic medication. Key safety considerations are not well-documented. Further research is needed to understand the pharmacology and clinical use of gitoxin.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}