{"id":"ginkgo-biloba-extract-gbe","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Bleeding risk (with anticoagulants)"}]},"_chembl":{"chemblId":"CHEMBL2108466","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"GBE contains flavonoids and terpenoids that act as free radical scavengers and inhibit platelet-activating factor, thereby enhancing cerebral and peripheral microcirculation. It also modulates neurotransmitter function and reduces neuroinflammation, which may contribute to cognitive and vascular benefits.","oneSentence":"Ginkgo biloba extract improves blood flow and reduces oxidative stress through antioxidant and antiplatelet mechanisms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:39:54.077Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Age-related cognitive decline and dementia"},{"name":"Peripheral arterial occlusive disease"},{"name":"Tinnitus"},{"name":"Vertigo and dizziness"}]},"trialDetails":[{"nctId":"NCT04846179","phase":"PHASE4","title":"To Evaluate the Effect of Ginkgo Biloba Extract on Optic Nerve Head Perfusion Examined Using OCTA","status":"COMPLETED","sponsor":"Nova Scotia Health Authority","startDate":"2021-05-01","conditions":"Glaucoma","enrollment":15},{"nctId":"NCT04192656","phase":"PHASE4","title":"The Effect of PAP on ISSHL Comorbided With OSA","status":"RECRUITING","sponsor":"Beijing Tsinghua Chang Gung Hospital","startDate":"2019-11-01","conditions":"Sudden Hearing Loss, Obstructive Sleep Apnea","enrollment":102},{"nctId":"NCT01046292","phase":"PHASE4","title":"Effect of Ginkgo Biloba Special Extract LI 1370 on Dual-tasking in Patients With MCI","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2010-01","conditions":"Mild Cognitive Impairment","enrollment":50},{"nctId":"NCT01038050","phase":"PHASE4","title":"Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2009-10","conditions":"Type 2 Diabetes Mellitus, Coronary Artery Disease","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":360,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cerenin(Ginkgo Biloba Extract) film-coated 40 mg"],"phase":"marketed","status":"active","brandName":"Ginkgo Biloba Extract (GBE)","genericName":"Ginkgo Biloba Extract (GBE)","companyName":"Taipei Veterans General Hospital, Taiwan","companyId":"taipei-veterans-general-hospital-taiwan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ginkgo Biloba Extract (GBE) has been studied in clinical trials for various conditions, including Sudden Hearing Loss, Obstructive Sleep Apnea, Mild Cognitive Impairment, Type 2 Diabetes Mellitus, and Coronary Artery Disease. The exact mechanism of GBE is unknown, but it is known by various synonyms, including EGB 761 and Ginkgo.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}