{"id":"gi265235","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug blocks integrase, an HIV enzyme essential for inserting viral DNA into the human genome. By inhibiting this step, it prevents HIV replication and reduces viral load in infected individuals. It is typically used as part of combination antiretroviral therapy.","oneSentence":"GI265235 is an HIV integrase strand transfer inhibitor that prevents HIV from integrating its genetic material into host cell DNA.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:39:23.967Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV-1 infection in treatment-experienced adults"}]},"trialDetails":[{"nctId":"NCT00441688","phase":"PHASE4","title":"Prospective Epidemiological Study Of The Prevalence Of HLAB*5701 In HIV-1 Infected Patients","status":"COMPLETED","sponsor":"ViiV Healthcare","startDate":"2007-03-15","conditions":"Infection, Human Immunodeficiency Virus","enrollment":974}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"GI265235","genericName":"GI265235","companyName":"ViiV Healthcare","companyId":"viiv-healthcare","modality":"Small molecule","firstApprovalDate":"","aiSummary":"GI265235 is an HIV integrase strand transfer inhibitor that prevents HIV from integrating its genetic material into host cell DNA. Used for HIV-1 infection in treatment-experienced adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}