{"id":"gentisic-acid","rwe":[{"pmid":"41752363","year":"2026","title":"LC-ESI-MS/MS Analysis of Echium asperrimum from the Algerian Aurès Region: Antioxidant, Antimicrobial, Cholinesterase Inhibitory, and Antiproliferative Activities.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41722109","year":"2026","title":"In Vitro Antioxidant and Anti-Inflammatory Activity and Phenolic Compound Determination of King Oyster Mushroom Pleurotus eryngii (Agaricomycetes) from Algeria.","finding":"","journal":"International journal of medicinal mushrooms","studyType":"Clinical Study"},{"pmid":"41656462","year":"2026","title":"Chemical armed allies promote plant resistance to pathogen: The contribution of arbuscular mycorrhizal fungi to an invasive weed.","finding":"","journal":"Mycorrhiza","studyType":"Clinical Study"},{"pmid":"41596161","year":"2026","title":"Chemical Fingerprint of Floral Nectar in Apple (Malus sp.) Cultivars Grown in Norway.","finding":"","journal":"Antioxidants (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41565121","year":"2026","title":"Chemical composition and evaluation of the antipsoriatic potential of Cistus sintenisii in mouse model.","finding":"","journal":"Fitoterapia","studyType":"Clinical Study"}],"tags":[{"label":"gentisic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Carbonic anhydrase 2","category":"target"},{"label":"CA2","category":"gene"},{"label":"CA1","category":"gene"},{"label":"CA9","category":"gene"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"gensigen","offLabel":[],"synonyms":["sodium gentisate","gentisic acid","carboxyhydroquinone","gensigen","gensigon","gentisinic acid","hydroquinonecarboxylic acid"],"timeline":[],"approvals":[],"brandName":"Gensigen","ecosystem":[],"mechanism":{"target":"Arachidonate 5-lipoxygenase, Carbonic anhydrase 1, Carbonic anhydrase 12","targets":[{"gene":"CA2","source":"DrugCentral","target":"Carbonic anhydrase 2","protein":"Carbonic anhydrase 2"},{"gene":"CA1","source":"DrugCentral","target":"Carbonic anhydrase 1","protein":"Carbonic anhydrase 1"},{"gene":"CA9","source":"DrugCentral","target":"Carbonic anhydrase 9","protein":"Carbonic anhydrase 9"},{"gene":"CA12","source":"DrugCentral","target":"Carbonic anhydrase 12","protein":"Carbonic anhydrase 12"},{"gene":"CA14","source":"DrugCentral","target":"Carbonic anhydrase 14","protein":"Carbonic anhydrase 14"},{"gene":"CA7","source":"DrugCentral","target":"Carbonic anhydrase 7","protein":"Carbonic anhydrase 7"},{"gene":"ALOX5","source":"DrugCentral","target":"Arachidonate 5-lipoxygenase","protein":"Arachidonate 5-lipoxygenase"}],"modality":"Small Molecule","drugClass":"gentisic acid","explanation":"Think of carbonic anhydrase 2 like a pump that helps move fluids and electrolytes in and out of cells. When gensigen blocks this pump, it can affect the balance of fluids and electrolytes in the body, which can be helpful in treating certain conditions. However, this can also lead to side effects if not managed properly.","oneSentence":"Gensigen works by blocking the enzyme carbonic anhydrase 2, which helps regulate the balance of fluids and electrolytes in the body.","technicalDetail":"Gensigen inhibits the enzyme carbonic anhydrase 2 (CA2) through a competitive binding mechanism, reducing its activity and altering the regulation of fluid and electrolyte balance in the body."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3260","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=gentisic%20acid","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=gentisic acid","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:44:37.027241","biosimilars":[],"competitors":[{"drugName":"acetazolamide","drugSlug":"acetazolamide","fdaApproval":"1953-07-27","genericCount":29,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"acetohydroxamic acid","drugSlug":"acetohydroxamic-acid","fdaApproval":"1983-05-31","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"bendroflumethiazide","drugSlug":"bendroflumethiazide","fdaApproval":"1959-12-07","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"benzthiazide","drugSlug":"benzthiazide","fdaApproval":"1960-10-14","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"bortezomib","drugSlug":"bortezomib","fdaApproval":"2003-05-13","patentExpiry":"Sep 23, 2042","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"brinzolamide","drugSlug":"brinzolamide","fdaApproval":"1998-04-01","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"cefuroxime","drugSlug":"cefuroxime","fdaApproval":"1983-10-19","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"celecoxib","drugSlug":"celecoxib","fdaApproval":"1998-12-31","patentExpiry":"May 27, 2036","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"chlorothiazide","drugSlug":"chlorothiazide","fdaApproval":"1958-09-04","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"chlortalidone","drugSlug":"chlortalidone","fdaApproval":"1960-04-07","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"gentisic acid","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetazolamide","brandName":"acetazolamide","genericName":"acetazolamide","approvalYear":"1953","relationship":"same-target"},{"drugId":"acetohydroxamic-acid","brandName":"acetohydroxamic acid","genericName":"acetohydroxamic acid","approvalYear":"1983","relationship":"same-target"},{"drugId":"bendroflumethiazide","brandName":"bendroflumethiazide","genericName":"bendroflumethiazide","approvalYear":"1959","relationship":"same-target"},{"drugId":"benzthiazide","brandName":"benzthiazide","genericName":"benzthiazide","approvalYear":"1960","relationship":"same-target"},{"drugId":"bortezomib","brandName":"bortezomib","genericName":"bortezomib","approvalYear":"2003","relationship":"same-target"},{"drugId":"brinzolamide","brandName":"brinzolamide","genericName":"brinzolamide","approvalYear":"1998","relationship":"same-target"},{"drugId":"cefuroxime","brandName":"cefuroxime","genericName":"cefuroxime","approvalYear":"1983","relationship":"same-target"},{"drugId":"celecoxib","brandName":"celecoxib","genericName":"celecoxib","approvalYear":"1998","relationship":"same-target"},{"drugId":"chlorothiazide","brandName":"chlorothiazide","genericName":"chlorothiazide","approvalYear":"1958","relationship":"same-target"},{"drugId":"chlortalidone","brandName":"chlortalidone","genericName":"chlortalidone","approvalYear":"1960","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT06991738","phase":"PHASE1,PHASE2","title":"177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer","status":"NOT_YET_RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2026-04-01","conditions":["Thyroid Cancer"],"enrollment":18,"completionDate":"2032-08-01"},{"nctId":"NCT04069299","phase":"","title":"Use of 68Ga-dotatate PET Scan in Neuroendocrine Carcinoma of the GI Tract","status":"ACTIVE_NOT_RECRUITING","sponsor":"H. Lee Moffitt Cancer Center and Research Institute","startDate":"2019-09-25","conditions":["Neuroendocrine Carcinoma"],"enrollment":30,"completionDate":"2026-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"010196","UNII":"VP36V95O3T","CHEBI":"CHEBI:17189","INN_ID":"756","RXNORM":"1368641","UMLSCUI":"C0045555","ChEMBL_ID":"CHEMBL1461","PDB_CHEM_ID":"GTQ","PUBCHEM_CID":"3469","SECONDARY_CAS_RN":"4955-90-2"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":616,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb 7","pmid":"41752363","title":"LC-ESI-MS/MS Analysis of Echium asperrimum from the Algerian Aurès Region: Antioxidant, Antimicrobial, Cholinesterase Inhibitory, and Antiproliferative Activities.","journal":"Molecules (Basel, Switzerland)"},{"date":"2026","pmid":"41722109","title":"In Vitro Antioxidant and Anti-Inflammatory Activity and Phenolic Compound Determination of King Oyster Mushroom Pleurotus eryngii (Agaricomycetes) from Algeria.","journal":"International journal of medicinal mushrooms"},{"date":"2026 Feb 9","pmid":"41656462","title":"Chemical armed allies promote plant resistance to pathogen: The contribution of arbuscular mycorrhizal fungi to an invasive weed.","journal":"Mycorrhiza"},{"date":"2026 Jan 13","pmid":"41596161","title":"Chemical Fingerprint of Floral Nectar in Apple (Malus sp.) Cultivars Grown in Norway.","journal":"Antioxidants (Basel, Switzerland)"},{"date":"2026 Mar","pmid":"41565121","title":"Chemical composition and evaluation of the antipsoriatic potential of Cistus sintenisii in mouse model.","journal":"Fitoterapia"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Gentisic acid is a dihydroxybenzoic acid and a derivative of benzoic acid, which is a minor product of the metabolic breakdown of aspirin. It is excreted by the kidneys.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}