{"id":"gentian-violet-1-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin staining/discoloration"},{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gentian violet (crystal violet) exerts antimicrobial effects by binding to and damaging microbial cell membranes, disrupting their integrity and function. It also intercalates into DNA and RNA, interfering with nucleic acid synthesis, and generates reactive oxygen species that cause oxidative damage to pathogens. These multiple mechanisms make it effective against a broad spectrum of bacteria, fungi, and some protozoa.","oneSentence":"Gentian violet is a triphenylmethane dye that disrupts microbial cell membranes and inhibits bacterial and fungal growth through intercalation into nucleic acids and oxidative stress generation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:04.591Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical treatment of bacterial and fungal skin infections"},{"name":"Oral candidiasis (thrush)"},{"name":"Wound antisepsis and disinfection"}]},"trialDetails":[{"nctId":"NCT01427738","phase":"PHASE3","title":"Gentian Violet Vs. Nystatin Oral Suspension for Treatment of Oropharyngeal Candidiasis","status":"COMPLETED","sponsor":"Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections","startDate":"2011-06","conditions":"HIV-1 Infection","enrollment":221},{"nctId":"NCT00128323","phase":"PHASE3","title":"A Comparison of Gentian Violet (GV) Mouth Washes, Nystatin, and Ketoconazole Tabs in Treating Oropharyngeal Candidiasis","status":"COMPLETED","sponsor":"Kamuzu University of Health Sciences","startDate":"2002-11","conditions":"Candidiasis, Oral","enrollment":558}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Gentian violet 1% solution","genericName":"Gentian violet 1% solution","companyName":"Kamuzu University of Health Sciences","companyId":"kamuzu-university-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gentian violet is a triphenylmethane dye that disrupts microbial cell membranes and inhibits bacterial and fungal growth through intercalation into nucleic acids and oxidative stress generation. Used for Topical treatment of bacterial and fungal skin infections, Oral candidiasis (thrush), Wound antisepsis and disinfection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}