{"id":"gentian-violet-0-00165-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin staining/discoloration"},{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gentian violet (crystal violet) is a cationic dye that binds to nucleic acids and proteins in microorganisms, inhibiting their growth and reproduction. It has broad-spectrum activity against bacteria, fungi, and some parasites, making it useful as a topical antiseptic and antimicrobial agent. The dye's mechanism involves disruption of microbial cell membranes and interference with essential cellular processes.","oneSentence":"Gentian violet is a triphenylmethane dye that exerts antimicrobial and antifungal effects by intercalating into microbial DNA and disrupting cellular function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:14:00.105Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical treatment of bacterial and fungal skin infections"},{"name":"Oral candidiasis (thrush)"},{"name":"Wound antisepsis and disinfection"}]},"trialDetails":[{"nctId":"NCT01427738","phase":"PHASE3","title":"Gentian Violet Vs. Nystatin Oral Suspension for Treatment of Oropharyngeal Candidiasis","status":"COMPLETED","sponsor":"Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections","startDate":"2011-06","conditions":"HIV-1 Infection","enrollment":221},{"nctId":"NCT00128323","phase":"PHASE3","title":"A Comparison of Gentian Violet (GV) Mouth Washes, Nystatin, and Ketoconazole Tabs in Treating Oropharyngeal Candidiasis","status":"COMPLETED","sponsor":"Kamuzu University of Health Sciences","startDate":"2002-11","conditions":"Candidiasis, Oral","enrollment":558}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Gentian violet 0.00165% solution","genericName":"Gentian violet 0.00165% solution","companyName":"Kamuzu University of Health Sciences","companyId":"kamuzu-university-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gentian violet 0.00165% solution is a small molecule that inhibits DNA, classified as an inhibitor. It has been studied as a treatment for oral candidiasis and HIV-1 infection in clinical trials.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}