{"id":"genotonorm-somatropin","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Fluid retention"},{"rate":null,"effect":"Carpal tunnel syndrome"},{"rate":null,"effect":"Arthralgia"}]},"_chembl":{"chemblId":"CHEMBL1201621","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Somatropin mimics endogenous growth hormone by activating GH receptors on target tissues, promoting linear growth in children, increasing lean body mass, and enhancing metabolic function. It stimulates insulin-like growth factor 1 (IGF-1) production, which mediates many of growth hormone's anabolic and metabolic effects.","oneSentence":"Somatropin is a recombinant human growth hormone that binds to growth hormone receptors to stimulate growth, metabolism, and body composition changes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:47:21.546Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Growth hormone deficiency in children"},{"name":"Growth hormone deficiency in adults"},{"name":"Short stature associated with Turner syndrome"},{"name":"Chronic kidney disease-related growth failure"}]},"trialDetails":[{"nctId":"NCT00921609","phase":"","title":"Peri-operative Dynamics of the Growth Hormone Axis in Subjects With Acromegaly","status":"COMPLETED","sponsor":"Cedars-Sinai Medical Center","startDate":"2006-06","conditions":"Acromegaly","enrollment":20},{"nctId":"NCT07037420","phase":"PHASE2","title":"ALXN2420 Versus Placebo in Combination With Somatostatin Analogs in Participants With Acromegaly","status":"RECRUITING","sponsor":"Alexion Pharmaceuticals, Inc.","startDate":"2025-10-28","conditions":"Acromegaly","enrollment":60},{"nctId":"NCT06948214","phase":"PHASE3","title":"Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency","status":"RECRUITING","sponsor":"Lumos Pharma","startDate":"2026-04","conditions":"Growth Hormone Deficiency (GHD)","enrollment":150},{"nctId":"NCT07481734","phase":"PHASE2","title":"Tesamorelin for Reduction of Liver Fat in Adults With Fatty Liver Disease (Mock Study)","status":"RECRUITING","sponsor":"Hudson Biotech","startDate":"2026-02-02","conditions":"Metabolic Associated Steatotic Liver Disease, Nonalcoholic Steatohepatitis, Hepatic Steatosis","enrollment":120},{"nctId":"NCT07481656","phase":"PHASE4","title":"Effects of Recombinant Human Growth Hormone in Elderly Patients With Moderate to Severe Acute Brain Injury (GH-ABI-RCT)","status":"NOT_YET_RECRUITING","sponsor":"Anhui Provincial Hospital","startDate":"2026-04-10","conditions":"Acute Brain Injuries, Moderate to Severe Traumatic Brain Injury","enrollment":160},{"nctId":"NCT07036003","phase":"PHASE1, PHASE2","title":"Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR)","status":"RECRUITING","sponsor":"Dr. David Wasserstein","startDate":"2025-10-31","conditions":"Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)","enrollment":34},{"nctId":"NCT05470504","phase":"PHASE2","title":"Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2023-01-23","conditions":"Insulin Receptor Mutation, Partial Lipodystrophy","enrollment":25},{"nctId":"NCT06382155","phase":"PHASE2","title":"A Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature","status":"RECRUITING","sponsor":"BioMarin Pharmaceutical","startDate":"2024-10-21","conditions":"Idiopathic Short Stature","enrollment":100},{"nctId":"NCT00663611","phase":"PHASE1","title":"Growth Hormone Administration and the Human Immune System","status":"COMPLETED","sponsor":"National Institute on Aging (NIA)","startDate":"2006-10-19","conditions":"Healthy Volunteers","enrollment":66},{"nctId":"NCT05330325","phase":"PHASE3","title":"A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow","status":"ACTIVE_NOT_RECRUITING","sponsor":"Novo Nordisk A/S","startDate":"2022-08-10","conditions":"SGA, Turner Syndrome, Noonan Syndrome, ISS","enrollment":412},{"nctId":"NCT06927310","phase":"PHASE3","title":"The Efficacy and Safety of Inpegsomatropin Injection in Children With Idiopathic Short Stature","status":"RECRUITING","sponsor":"Xiamen Amoytop Biotech Co., Ltd.","startDate":"2025-04-28","conditions":"Idiopathic Short Stature","enrollment":300},{"nctId":"NCT07221851","phase":"PHASE3","title":"Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders","status":"RECRUITING","sponsor":"Ascendis Pharma A/S","startDate":"2025-12-12","conditions":"Turner Syndrome, Short Stature Homeobox Gene Mutation, Idiopathic Short Stature","enrollment":186},{"nctId":"NCT07450001","phase":"PHASE1, PHASE2","title":"A Study of GenSci134 in Children With Growth Hormone Deficiency (PGHD)","status":"NOT_YET_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2026-03-06","conditions":"Pediatric Growth Hormone Deficiency","enrollment":128},{"nctId":"NCT07450053","phase":"PHASE1, PHASE2","title":"A Study (Phase 1b/2) of GenSci134 in Children With Idiopathic Short Stature (ISS)","status":"NOT_YET_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2026-03-06","conditions":"Idiopathic Short Stature","enrollment":128},{"nctId":"NCT05681299","phase":"PHASE4","title":"Effects of GH and Lirglutide on AgRP","status":"RECRUITING","sponsor":"Columbia University","startDate":"2023-05-01","conditions":"Healthy, Growth Hormone Deficiency","enrollment":40},{"nctId":"NCT07309562","phase":"PHASE3","title":"The Efficacy and Safety of Inpegsomatropin Injection in Children With Short Stature Born Small for Gestational Age","status":"RECRUITING","sponsor":"Xiamen Amoytop Biotech Co., Ltd.","startDate":"2026-01-20","conditions":"Small for Gestational Age","enrollment":141},{"nctId":"NCT06930625","phase":"PHASE3","title":"A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs","status":"RECRUITING","sponsor":"Debiopharm International SA","startDate":"2025-11-26","conditions":"Acromegaly","enrollment":119},{"nctId":"NCT06668805","phase":"PHASE2","title":"A Basket Study of Vosoritide in Children With Turner Syndrome, Short Stature Homeobox-Containing Gene Deficiency, and Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment","status":"RECRUITING","sponsor":"BioMarin Pharmaceutical","startDate":"2024-11-22","conditions":"Short Stature Homeobox- Containing Gene SHOX Deficiency, Noonan Syndrome, Turner Syndrome","enrollment":54},{"nctId":"NCT07226089","phase":"PHASE3","title":"Comparison of Weekly Somatrogon to Daily Genotropin in Children Born Small for Gestational Age or With Idiopathic Short Stature.","status":"RECRUITING","sponsor":"Rabin Medical Center","startDate":"2026-02","conditions":"ISS, SGA","enrollment":254},{"nctId":"NCT07260500","phase":"PHASE2","title":"A Phase II Study of PEG-rhGH Injection for Short Children Born Small for Gestational Age: Efficacy, Safety, and Pharmacokinetics","status":"RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-11-11","conditions":"Short Stature Children Born Small for Gestational Age (SGA)","enrollment":72},{"nctId":"NCT07333521","phase":"","title":"Assessment of Body Composition in Children Treated With Growth Hormone for the Indication of Isolated Non-acquired Growth Hormone Deficiency.","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2026-01-13","conditions":"Isolated Non-acquired Growth Hormone Deficiency","enrollment":100},{"nctId":"NCT07173036","phase":"NA","title":"Evaluation of (Cardio)Metabolic and Auxological Outcomes of GHD Patients Under rhGH or LAGH With Stratification According to IGF-1 Levels","status":"NOT_YET_RECRUITING","sponsor":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","startDate":"2026-03-01","conditions":"Growth Hormone Deficiency","enrollment":300},{"nctId":"NCT05718570","phase":"","title":"A Study to Follow Patients With Adult Growth Hormone Deficiency (AGHD) Treated With Sogroya® for Long Term Safety Information","status":"ENROLLING_BY_INVITATION","sponsor":"Novo Nordisk A/S","startDate":"2023-02-03","conditions":"Adult Growth Hormone Deficiency","enrollment":400},{"nctId":"NCT06803589","phase":"EARLY_PHASE1","title":"Growth Hormone for the Treatment of Gastroparesis","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2024-10-22","conditions":"Gastroparesis","enrollment":10},{"nctId":"NCT06558422","phase":"PHASE1","title":"Human Models of Selective Insulin Resistance: Pancreatic Clamp","status":"NOT_YET_RECRUITING","sponsor":"Columbia University","startDate":"2027-01-01","conditions":"Insulin Resistance, Hyperinsulinemia, Metabolic Dysfunction Associated Steatotic Liver Disease","enrollment":36},{"nctId":"NCT05820672","phase":"","title":"A US Non-interventional, Effectiveness and Safety Study of Patients Treated With SKYTROFA","status":"RECRUITING","sponsor":"Ascendis Pharma Endocrinology Division A/S","startDate":"2023-03-20","conditions":"Growth Hormone Deficiency","enrollment":900},{"nctId":"NCT05775523","phase":"","title":"A Post-Authorisation Safety Study (PASS) of Patients Treated With Lonapegsomatropin","status":"RECRUITING","sponsor":"Ascendis Pharma Endocrinology Division A/S","startDate":"2023-03-20","conditions":"Growth Hormone Deficiency","enrollment":500},{"nctId":"NCT07246421","phase":"NA","title":"Glucagon Resistance in Patients With MASLD and T2DM","status":"RECRUITING","sponsor":"University of Aarhus","startDate":"2026-01-29","conditions":"Metabolic Associated Fatty Liver Disease, Type 2 Diabetes (T2DM)","enrollment":24},{"nctId":"NCT05509894","phase":"","title":"Korean Post-marketing Surveillance Ngenla® Pre-filled Pen Injection for the Treatment of Pediatric Patients With Growth Disturbance Due to Insufficient Secretion of Growth Hormone","status":"ACTIVE_NOT_RECRUITING","sponsor":"Pfizer","startDate":"2024-06-20","conditions":"Pediatric Growth Hormone Deficiency","enrollment":565},{"nctId":"NCT07359625","phase":"NA","title":"Effects of Ketone Bodies on Insulin Sensitivity","status":"RECRUITING","sponsor":"University of Aarhus","startDate":"2025-12-02","conditions":"Insulin Resistance, Obesity & Overweight, Energy Metabolism","enrollment":10},{"nctId":"NCT02616562","phase":"PHASE2","title":"Investigating Efficacy and Safety of Once-weekly NNC0195-0092 Treatment Compared to Daily Growth Hormone Treatment (Norditropin® FlexPro®) in Growth Hormone Treatment naïve Pre-pubertal Children With Growth Hormone Deficiency","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2016-03-31","conditions":"Growth Hormone Disorder, Growth Hormone Deficiency in Children","enrollment":76},{"nctId":"NCT07339436","phase":"NA","title":"Lower Body Plyometric Training Effects on Upper Body in Basketball Players","status":"COMPLETED","sponsor":"Birjand University of Medical Sciences","startDate":"2024-09-20","conditions":"Basketball Performance","enrollment":50},{"nctId":"NCT04697381","phase":"PHASE3","title":"Study of the Efficacy and Safety of Somatropin in Japanese Participants With PWS","status":"COMPLETED","sponsor":"Pfizer","startDate":"2021-02-09","conditions":"Prader-Willi Syndrome","enrollment":33},{"nctId":"NCT05724134","phase":"PHASE1","title":"Pancreatic Clamp in NAFLD","status":"COMPLETED","sponsor":"Columbia University","startDate":"2023-08-29","conditions":"Insulin Resistance, Prediabetic State, Hyperinsulinemia","enrollment":18},{"nctId":"NCT05690386","phase":"PHASE2","title":"A Trial to Investigate Different Doses of Lonapegsomatropin Compared to Somatropin in Individuals With Turner Syndrome","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ascendis Pharma Endocrinology Division A/S","startDate":"2023-02-15","conditions":"Turner Syndrome","enrollment":48},{"nctId":"NCT05171855","phase":"PHASE3","title":"A Trial to Investigate Long Term Efficacy and Safety of Lonapegsomatropin in Adults With Growth Hormone Deficiency","status":"COMPLETED","sponsor":"Ascendis Pharma Endocrinology Division A/S","startDate":"2021-12-16","conditions":"Adult Growth Hormone Deficiency, Endocrine System Diseases, Hormone Deficiency","enrollment":220},{"nctId":"NCT07323329","phase":"PHASE2, PHASE3","title":"Growth Hormone and Dehydroepiandrosterone Role in Vitro Fertilization","status":"RECRUITING","sponsor":"Beni-Suef University","startDate":"2025-10-10","conditions":"Infertility, Infertility (IVF Patients)","enrollment":165},{"nctId":"NCT06587035","phase":"","title":"A Study to Learn About Somatrogon in Patients With Pediatric Growth Hormone Deficiency (p GHD) in India.","status":"RECRUITING","sponsor":"Pfizer","startDate":"2025-01-30","conditions":"Dwarfism, Pituitary","enrollment":50},{"nctId":"NCT00227253","phase":"","title":"Chromosome 18 Clinical Research Center","status":"RECRUITING","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"1993-09","conditions":"Chromosome Aberrations, Growth Hormone Deficiency, Hypomyelination","enrollment":4000},{"nctId":"NCT05364684","phase":"PHASE2","title":"The Impact of Ibutamoren on Nonalcoholic Fatty Liver Disease","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2022-08-10","conditions":"NAFLD, Nonalcoholic Fatty Liver, NASH - Nonalcoholic Steatohepatitis","enrollment":12},{"nctId":"NCT04970654","phase":"PHASE3","title":"A Research Study in Chinese Children With a Low Level of Hormone to Grow. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a Day.","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2021-07-22","conditions":"Growth Hormone Deficiency in Children","enrollment":110},{"nctId":"NCT03811535","phase":"PHASE3","title":"A Research Study in Children With a Low Level of Hormone to Grow. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a Day (REAL4)","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2019-05-20","conditions":"Growth Hormone Deficiency in Children","enrollment":200},{"nctId":"NCT03878446","phase":"PHASE2","title":"A Research Study in Children Born Small and Who Stayed Small. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a Day","status":"ACTIVE_NOT_RECRUITING","sponsor":"Novo Nordisk A/S","startDate":"2019-07-04","conditions":"Short Stature Children Born Small for Gestational Age (SGA)","enrollment":62},{"nctId":"NCT01512524","phase":"NA","title":"Hormonal Deficiency in the Quality of Life of Patients With Traumatic Brain Injury","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2011-11-23","conditions":"Traumatic Brain Injury (TBI)","enrollment":88},{"nctId":"NCT04867317","phase":"PHASE3","title":"Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2025-01-13","conditions":"Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury","enrollment":172},{"nctId":"NCT03422081","phase":"","title":"Growth and Asymmetric diMethylArginine","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2014-06","conditions":"Growth Hormone Deficiency, Small-for-gestational Age","enrollment":23},{"nctId":"NCT05253287","phase":"PHASE2, PHASE3","title":"Growth Hormone in Decompensated Liver Cirrhosis","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2022-02-01","conditions":"Liver Cirrhosis, Fibrosis, End Stage Liver Disease","enrollment":96},{"nctId":"NCT05894876","phase":"","title":"A Study of the Genetic Basis of Response to Growth Hormone Treatment in Children With Idiopathic Short Stature","status":"TERMINATED","sponsor":"Novo Nordisk A/S","startDate":"2024-04-29","conditions":"Idiopathic Short Stature","enrollment":43},{"nctId":"NCT07264595","phase":"PHASE1, PHASE2","title":"A Study (Phase 1b/2) of GS3-007a Oral Treatment in Children With Growth Hormone Deficiency (PGHD)","status":"NOT_YET_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-12","conditions":"Pediatric Growth Hormone Deficiency","enrollment":88},{"nctId":"NCT00803179","phase":"PHASE1","title":"Growth Hormone Therapy for Wasting in Cystic Fibrosis","status":"TERMINATED","sponsor":"University of Massachusetts, Worcester","startDate":"2008-11","conditions":"Cystic Fibrosis","enrollment":5},{"nctId":"NCT07259564","phase":"PHASE2","title":"A Study of GS3-007a for Oral Suspension in the Diagnosis of Adult Growth Hormone Deficiency (AGHD)","status":"NOT_YET_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-12-19","conditions":"Adult Growth Hormone Deficiency (AGHD)","enrollment":120},{"nctId":"NCT06830525","phase":"","title":"Development of a Personalized Growth Hormone Treatment Profile (PGTP) Report for Pediatric Endocrinology","status":"COMPLETED","sponsor":"Luis Fernandez Luque","startDate":"2025-05-19","conditions":"Growth Hormone Deficiency (GHD)","enrollment":40},{"nctId":"NCT04066569","phase":"NA","title":"Reproducibility and Utility of OGTT in Acromegaly","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2020-08-24","conditions":"Acromegaly","enrollment":109},{"nctId":"NCT00597480","phase":"PHASE4","title":"Study of Growth-promoting and Metabolic Effects of Growth Hormone (rhGH)","status":"TERMINATED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2008-01","conditions":"Small for Gestational Age","enrollment":10},{"nctId":"NCT03375788","phase":"PHASE2","title":"Growth Hormone Releasing Hormone Analog to Improve Nonalcoholic Fatty Liver Disease and Associated Cardiovascular Risk","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2019-01-17","conditions":"Non-Alcoholic Fatty Liver Disease, Obesity, Obesity, Abdominal","enrollment":51},{"nctId":"NCT06571487","phase":"","title":"Growth Hormone Resistance of Beta-cells","status":"RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2025-10-22","conditions":"Gestational Diabetes, Obesity, Healthy","enrollment":30},{"nctId":"NCT03882034","phase":"PHASE3","title":"Safety and Efficacy of Pegvisomant in Children With Growth Hormone Excess","status":"COMPLETED","sponsor":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","startDate":"2019-10-21","conditions":"Pituitary Disease","enrollment":12},{"nctId":"NCT04020913","phase":"","title":"Skeletal Muscle Effects of GH in Boys","status":"COMPLETED","sponsor":"Nemours Children's Clinic","startDate":"2019-07-22","conditions":"Growth Hormone Deficiency, Idiopathic Short Stature","enrollment":45},{"nctId":"NCT05602766","phase":"","title":"Ngenla Subcutaneous Injection Special Investigation","status":"ACTIVE_NOT_RECRUITING","sponsor":"Pfizer","startDate":"2023-02-06","conditions":"Growth Hormone Deficiency Without Epiphyseal Closure","enrollment":1},{"nctId":"NCT05250063","phase":"PHASE2","title":"Phase 2 Study of LUM-201 in Children Who Have Previously Completed the LUM-201-01 Trial (OraGrowtH213)","status":"COMPLETED","sponsor":"Lumos Pharma","startDate":"2022-02-18","conditions":"Growth Hormone Deficiency","enrollment":18},{"nctId":"NCT03091374","phase":"PHASE2","title":"Impact of Recombinant Human Growth Hormone on HIV Persistence","status":"COMPLETED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2016-12","conditions":"Human Immunodeficiency Virus, Growth Hormone Treatment","enrollment":22},{"nctId":"NCT03972345","phase":"","title":"Influence of Adherence to Growth Hormone Therapy (GHT) With Norditropin® on Near Final Height in Patients With Growth Hormone Deficiency (GHD) and Born Small for Gestational Age (SGA)","status":"ENROLLING_BY_INVITATION","sponsor":"Novo Nordisk A/S","startDate":"2019-06-21","conditions":"Growth Hormone Deficiency in Children, Born Small for Gestational Age","enrollment":750},{"nctId":"NCT05308927","phase":"","title":"French Registry of Children Treated With Norditropin® for Short Stature Associated With Noonan Syndrome","status":"ENROLLING_BY_INVITATION","sponsor":"Novo Nordisk A/S","startDate":"2022-03-16","conditions":"Noonan Syndrome","enrollment":221},{"nctId":"NCT05746650","phase":"NA","title":"Improving Tissue Repair After Injury in the Muscle-tendon Interface Muscle Tissue Injury","status":"RECRUITING","sponsor":"Bispebjerg Hospital","startDate":"2023-02-24","conditions":"Muscle Injury","enrollment":40},{"nctId":"NCT07171723","phase":"PHASE1, PHASE2","title":"Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment","status":"RECRUITING","sponsor":"University Hospital, Gentofte, Copenhagen","startDate":"2025-09-01","conditions":"Obesity &Amp; Overweight","enrollment":24},{"nctId":"NCT05195437","phase":"","title":"Evolution of the Quality of Life of Short Statured Children Treated With Growth Hormone : Evaluation at Adult Size","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2022-03-08","conditions":"Growth Hormone Treatment","enrollment":36},{"nctId":"NCT06037473","phase":"","title":"The Efficacy and Safety of PEGylated GH for the Treatment of Short Stature in Chinese Children-GLOBE Reg","status":"RECRUITING","sponsor":"Beijing Children's Hospital","startDate":"2023-08-01","conditions":"Growth Hormone Treatment, Growth Disorders","enrollment":2600},{"nctId":"NCT06294860","phase":"","title":"Biological Age in Children With GH Deficiency Undergoing Hormone Replacement Therapy","status":"COMPLETED","sponsor":"Istituto Auxologico Italiano","startDate":"2023-06-19","conditions":"Growth Hormone Deficiency, Short Stature","enrollment":10},{"nctId":"NCT06109935","phase":"","title":"Special Use-results Surveillance on Long Term Use of Sogroya® in Children With Short Stature Due to Growth Hormone Deficiency Where Epiphysial Discs Are Not Closed","status":"ENROLLING_BY_INVITATION","sponsor":"Novo Nordisk A/S","startDate":"2023-10-04","conditions":"Growth Hormone Deficiency in Children","enrollment":200},{"nctId":"NCT01809808","phase":"","title":"A Prospective Study of Outcome After Therapy for Acromegaly","status":"COMPLETED","sponsor":"Columbia University","startDate":"2003-09","conditions":"Acromegaly","enrollment":280},{"nctId":"NCT05645211","phase":"","title":"The AgRP and GH/IGF-1 Axis in Children","status":"NOT_YET_RECRUITING","sponsor":"Columbia University","startDate":"2026-06-10","conditions":"Growth Hormone Deficiency","enrollment":156},{"nctId":"NCT07126288","phase":"PHASE2, PHASE3","title":"Evaluating the Efficacy and Safety of GB08 Injection in Pediatric Patients With Growth Hormone Deficiency","status":"NOT_YET_RECRUITING","sponsor":"Shenzhen Kexing Pharmaceutical Co., Ltd.","startDate":"2025-08-31","conditions":"Growth Hormone Deficiency in Children, Growth Hormone Deficiency (GHD), Growth Hormone","enrollment":268},{"nctId":"NCT07129759","phase":"PHASE3","title":"Phase 3 Long Term Safety Extension Study of LUM-201 in Children With Growth Hormone Deficiency","status":"NOT_YET_RECRUITING","sponsor":"Lumos Pharma","startDate":"2026-09","conditions":"Growth Hormone Deficiency (GHD)","enrollment":150},{"nctId":"NCT03255694","phase":"PHASE2","title":"A Study Extension Period of PEG-somatropin (Pegylated-somatropin) in the Treatment of Children With Idiopathic Short Stature","status":"ACTIVE_NOT_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2017-05-12","conditions":"Dwarfism","enrollment":360},{"nctId":"NCT05355272","phase":"PHASE2","title":"Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)","status":"RECRUITING","sponsor":"Baylor College of Medicine","startDate":"2024-03-11","conditions":"Gulf War Syndrome, Adult Growth Hormone Deficiency","enrollment":20},{"nctId":"NCT05293366","phase":"","title":"LOng COvid COmorbidities: Endocrine,Metabolic,Neuropsychiatric,Muscle,Cardiovascular,Pulmonary,Dermatologic Dysfunctions","status":"RECRUITING","sponsor":"Federico II University","startDate":"2022-01-27","conditions":"Long Covid-19","enrollment":100},{"nctId":"NCT06797505","phase":"PHASE1","title":"A Bioequivalence Study of Two Different PEG-rhGH Preparations","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-02-10","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":87},{"nctId":"NCT06433375","phase":"NA","title":"Evaluation of the Efficacy of Growth Hormone, EndoSeal MTA Sealer, and Their Combination on Healing of Periapical Pathosis","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2023-04-01","conditions":"Growth Hormone, EndoSeal MTA, Periapical Pathosis","enrollment":28},{"nctId":"NCT06554717","phase":"PHASE2","title":"Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-07-07","conditions":"HIV-1-infection, Frailty, Impaired Physical Function","enrollment":100},{"nctId":"NCT02968004","phase":"PHASE3","title":"Safety and Efficacy Phase 3 Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children","status":"COMPLETED","sponsor":"OPKO Health, Inc.","startDate":"2016-12","conditions":"Pediatric Growth Hormone Deficiency","enrollment":224},{"nctId":"NCT06571500","phase":"","title":"Growth Hormone Resistance of Beta-cells in Women and People","status":"RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2025-07-15","conditions":"Healthy, Obesity","enrollment":30},{"nctId":"NCT07016802","phase":"PHASE1","title":"A Clinical Study of GenSci134 in Healthy Male Adults","status":"RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-06-23","conditions":"Healthy Volunteers","enrollment":64},{"nctId":"NCT05382637","phase":"PHASE2","title":"Growth Hormone in a Patient With a Dominant-Negative GHR Mutation","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's National Research Institute","startDate":"2022-08-26","conditions":"Growth Disorders","enrollment":1},{"nctId":"NCT07026812","phase":"","title":"Impact of Screens on Children's Growth","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2022-09-26","conditions":"Growth Disorders","enrollment":150},{"nctId":"NCT00209235","phase":"NA","title":"Albright Hereditary Osteodystrophy: Natural History, Growth, and Cognitive/Behavioral Assessments","status":"RECRUITING","sponsor":"Connecticut Children's Medical Center","startDate":"2003-01","conditions":"Pseudohypoparathyroidism Type 1A, Albright Hereditary Osteodystrophy, Pseudopseudohypoparathyroidism","enrollment":600},{"nctId":"NCT02375620","phase":"PHASE2","title":"Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat SGA Children With Short Stature","status":"ACTIVE_NOT_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2015-04-23","conditions":"Short Stature Children Born Small for Gestational Age (SGA)","enrollment":96},{"nctId":"NCT06564753","phase":"PHASE2","title":"Phase 2 Trials of NA-931 to Study Subjects Who Are Obese With at Least One Weight-related Comorbid Condition","status":"COMPLETED","sponsor":"Biomed Industries, Inc.","startDate":"2024-07-19","conditions":"Weight Loss, Obesity, Body Weight","enrollment":126},{"nctId":"NCT03500913","phase":"","title":"Adipose Tissue and Serum Inflammation in GH Deficiency","status":"COMPLETED","sponsor":"Columbia University","startDate":"2019-05-19","conditions":"Growth Hormone Deficiency","enrollment":19},{"nctId":"NCT03225755","phase":"","title":"Adipose Tissue and Circulating Markers of Inflammation in GH Deficiency and Changes With GH Therapy","status":"COMPLETED","sponsor":"Columbia University","startDate":"2017-08-01","conditions":"Growth Hormone Deficiency","enrollment":7},{"nctId":"NCT04375657","phase":"PHASE2","title":"Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial","status":"RECRUITING","sponsor":"Intervene Immune, Inc.","startDate":"2020-11-23","conditions":"Epigenetic Aging, Immunosenescence","enrollment":85},{"nctId":"NCT06295341","phase":"","title":"Short Stature and Psychological Well-being","status":"COMPLETED","sponsor":"Istituto Auxologico Italiano","startDate":"2023-05-10","conditions":"Short Stature, Short; Stature, Psychosocial","enrollment":80},{"nctId":"NCT05187377","phase":"PHASE2","title":"A Controlled Trial of Growth Hormone in Phelan-McDermid Syndrome and Idiopathic Autism","status":"COMPLETED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2022-01-19","conditions":"Phelan-McDermid Syndrome, Autism Spectrum Disorder (ASD)","enrollment":32},{"nctId":"NCT06743997","phase":"PHASE1","title":"A Study to Compare Eutropin Formulations in Healthy Volunteers for Bioavailability, Safety, and Tolerability","status":"COMPLETED","sponsor":"LG Chem","startDate":"2025-01-13","conditions":"Healthy Volunteers","enrollment":48},{"nctId":"NCT02500316","phase":"PHASE2","title":"Long Term Follow up Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children","status":"COMPLETED","sponsor":"OPKO Health, Inc.","startDate":"2014-02","conditions":"Growth Hormone Deficiency (GHD)","enrollment":48},{"nctId":"NCT05230550","phase":"","title":"Post-Marketing Surveillance (Special Use-results Surveillance on Long-term Use) With Sogroya®","status":"ENROLLING_BY_INVITATION","sponsor":"Novo Nordisk A/S","startDate":"2022-02-03","conditions":"Adult Growth Hormone Deficiency","enrollment":200},{"nctId":"NCT06135168","phase":"PHASE1","title":"A Clinical Trail to Compare Pharmacokinetics of Two PEG-rhGH Injections With Different Preparations","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2023-10-31","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":60},{"nctId":"NCT06135155","phase":"PHASE1","title":"A Clinical Trial to Compare Pharmacokinetics of Two Different PEG-rhGH Preparations","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2023-11-06","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":48},{"nctId":"NCT06385145","phase":"PHASE1","title":"A Bioavailability Study of Two Different PEG-rhGH Preparations.","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2024-05-08","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":16},{"nctId":"NCT06907121","phase":"PHASE2, PHASE3","title":"Investigation of Growth Hormone and Platelet-Rich Plasma on Joint Health","status":"NOT_YET_RECRUITING","sponsor":"Integrant Pty Ltd","startDate":"2025-06-01","conditions":"Arthritis Ankle, Arthritis Knee","enrollment":60},{"nctId":"NCT06900335","phase":"","title":"Functional Connectome in Prader-Willi Syndrome: Neuroimaging and AI to Assess Therapeutic Impact","status":"COMPLETED","sponsor":"Corporacion Parc Tauli","startDate":"2025-03-01","conditions":"Prader Willi Syndrome, Hyperphagia, Behavior Disorders","enrollment":101}],"_emaApprovals":[],"_faersSignals":[{"count":3,"reaction":"CONDITION AGGRAVATED"},{"count":2,"reaction":"ACIDOSIS"},{"count":2,"reaction":"ANAEMIA"},{"count":2,"reaction":"CYST"},{"count":2,"reaction":"CYTOLYTIC HEPATITIS"},{"count":2,"reaction":"EPILEPSY"},{"count":2,"reaction":"POST PROCEDURAL COMPLICATION"},{"count":2,"reaction":"RENAL FAILURE ACUTE"},{"count":2,"reaction":"RESPIRATORY DISTRESS"},{"count":2,"reaction":"VOMITING"}],"_approvalHistory":[],"publicationCount":275,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Genotonorm (Somatropin)","genericName":"Genotonorm (Somatropin)","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Somatropin is a recombinant human growth hormone that binds to growth hormone receptors to stimulate growth, metabolism, and body composition changes. Used for Growth hormone deficiency in children, Growth hormone deficiency in adults, Short stature associated with Turner syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}