{"id":"genolar-symbicort","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Oral candidiasis"},{"rate":null,"effect":"Hoarseness"}]},"_chembl":{"chemblId":"CHEMBL1370","moleculeType":"Small molecule","molecularWeight":"430.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Genolar® contains formoterol, which activates beta-2 adrenergic receptors on airway smooth muscle to cause bronchodilation, while Symbicort® (budesonide/formoterol) provides both anti-inflammatory effects via glucocorticoid receptor activation and additional bronchodilation. The combination addresses both the inflammatory and obstructive components of chronic airway disease.","oneSentence":"This combination product pairs a long-acting beta-2 agonist (formoterol) with an inhaled corticosteroid (budesonide) to reduce airway inflammation and improve bronchial smooth muscle relaxation in asthma and COPD.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:13:54.229Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma maintenance therapy"},{"name":"Chronic obstructive pulmonary disease (COPD)"}]},"trialDetails":[{"nctId":"NCT04607629","phase":"PHASE3","title":"An Efficacy and Safety Study of Genolar® and Xolar® in the Persistent Atopic Bronchial Asthma","status":"COMPLETED","sponsor":"AO GENERIUM","startDate":"2018-06-20","conditions":"Bronchial Asthma","enrollment":192}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":221,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["omalizumab & (budesonide+formoterol)","GNR-044 & (budesonide+formoterol)"],"phase":"phase_3","status":"active","brandName":"Genolar® + Symbicort®","genericName":"Genolar® + Symbicort®","companyName":"AO GENERIUM","companyId":"ao-generium","modality":"Biologic","firstApprovalDate":"","aiSummary":"This combination product pairs a long-acting beta-2 agonist (formoterol) with an inhaled corticosteroid (budesonide) to reduce airway inflammation and improve bronchial smooth muscle relaxation in asthma and COPD. Used for Asthma maintenance therapy, Chronic obstructive pulmonary disease (COPD).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}