{"id":"generic-sevoflurane","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Postoperative nausea and vomiting"},{"rate":"5-15","effect":"Emergence agitation"},{"rate":"1-5","effect":"Airway irritation"},{"rate":"10-20","effect":"Hypotension"},{"rate":"5-10","effect":"Bradycardia"}]},"_chembl":{"chemblId":"CHEMBL1200694","moleculeType":"Small molecule","molecularWeight":"200.05"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sevoflurane acts primarily as a positive allosteric modulator of GABA-A receptors and an antagonist of NMDA receptors, leading to depression of the central nervous system. It produces rapid induction and emergence from anesthesia with minimal airway irritation, making it suitable for both inhalational induction and maintenance of general anesthesia across diverse surgical and procedural settings.","oneSentence":"Sevoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory neurotransmission in the central nervous system to produce unconsciousness and anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:02.140Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia in adults and pediatric patients undergoing surgery"},{"name":"Sedation in intensive care settings"}]},"trialDetails":[{"nctId":"NCT03100604","phase":"NA","title":"The Effect of General Anesthesia on the Middle Ear Pressure","status":"COMPLETED","sponsor":"Trakya University","startDate":"2013-08","conditions":"Ear Deformities, Acquired","enrollment":50},{"nctId":"NCT01792063","phase":"PHASE4","title":"Two Different Preparations of Sevoflurane in Induction","status":"COMPLETED","sponsor":"Istanbul University","startDate":"2013-02","conditions":"Coughing on Induction, Vapors; Inhalation","enrollment":200},{"nctId":"NCT01096212","phase":"PHASE4","title":"Efficacy and Safety of Sevofran in Patients Scheduled for Elective Surgery Under General Anesthesia","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2008-09","conditions":"General Anesthesia, Sevoflurane, Generic Drugs","enrollment":178}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sevofran® (Hana Pharmacy, Co. Ltd, Seoul, Korea)"],"phase":"marketed","status":"active","brandName":"generic sevoflurane","genericName":"generic sevoflurane","companyName":"Asan Medical Center","companyId":"asan-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sevoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory neurotransmission in the central nervous system to produce unconsciousness and anesthesia. Used for Induction and maintenance of general anesthesia in adults and pediatric patients undergoing surgery, Sedation in intensive care settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}