{"id":"general-anesthetic","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Postoperative nausea and vomiting"},{"rate":null,"effect":"Emergence delirium"}]},"_chembl":{"chemblId":"CHEMBL5878815","moleculeType":null,"molecularWeight":"396.27"},"_fixedAt":"2026-03-30T16:41:25.874408","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"General anesthetics work through multiple mechanisms including enhancement of inhibitory GABAergic neurotransmission and/or suppression of excitatory glutamatergic signaling in the brain. This results in loss of consciousness, suppression of reflexes, and analgesia. The specific molecular targets vary depending on the anesthetic agent used (e.g., propofol acts on GABA-A receptors, while nitrous oxide and ketamine have different primary targets).","oneSentence":"General anesthetics depress the central nervous system to produce unconsciousness, analgesia, and muscle relaxation for surgical procedures.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:31:07.502Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/General_anaesthetic","title":"General anaesthetic","extract":"General anaesthetics are often defined as compounds that induce a loss of consciousness in humans or loss of righting reflex in animals. Clinical definitions are also extended to include an induced coma that causes lack of awareness to painful stimuli, sufficient to facilitate surgical applications in clinical and veterinary practice. General anaesthetics do not act as analgesics and should also not be confused with sedatives. General anaesthetics are a structurally diverse group of compounds whose mechanisms encompass multiple biological targets involved in the control of neuronal pathways. The precise workings are the subject of some debate and ongoing research."},"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia for surgical procedures"}]},"_fixedFields":["pubmed(2549)"],"trialDetails":[{"nctId":"NCT07496632","phase":"NA","title":"Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients\"","status":"NOT_YET_RECRUITING","sponsor":"Bangladesh Medical University","startDate":"2026-04","conditions":"Scalp Block","enrollment":72},{"nctId":"NCT07494006","phase":"","title":"Spontaneous Breathing Mode: A Risk for Hypoxemia During OLV?","status":"ENROLLING_BY_INVITATION","sponsor":"Peking University People's Hospital","startDate":"2025-07-15","conditions":"Lung Cancer, OLV, Hypoxemia During Surgery","enrollment":44},{"nctId":"NCT07191652","phase":"","title":"The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat 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