{"id":"general-anesthesia-ga","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Postoperative nausea and vomiting"},{"rate":"5-15","effect":"Emergence delirium"},{"rate":"variable","effect":"Hypotension"},{"rate":"variable","effect":"Respiratory depression"},{"rate":"variable","effect":"Postoperative cognitive dysfunction"}]},"_chembl":{"chemblId":"CHEMBL1200994","moleculeType":"Small molecule","molecularWeight":"256.03"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"General anesthesia typically involves a combination of agents (intravenous induction agents, inhaled volatile anesthetics, opioids, and neuromuscular blockers) that work synergistically. These agents enhance inhibitory GABAergic neurotransmission, inhibit excitatory glutamatergic signaling, and modulate other ion channels and receptors in the CNS to produce loss of consciousness and suppression of protective airway reflexes. The exact molecular mechanisms remain incompletely understood but involve multiple targets including GABA-A receptors, NMDA receptors, and potassium channels.","oneSentence":"General anesthesia depresses the central nervous system through multiple molecular pathways to produce unconsciousness, analgesia, and muscle relaxation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:31:07.143Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia for surgical procedures"},{"name":"Sedation in intensive care settings"}]},"trialDetails":[{"nctId":"NCT07460310","phase":"NA","title":"Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2026-03-01","conditions":"Ankle Sprain, Ankle (Ligaments); Instability (Old Injury), Pain 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