{"id":"gelaspan-4","safety":{"commonSideEffects":[{"rate":null,"effect":"Anaphylactic/anaphylactoid reactions"},{"rate":null,"effect":"Coagulopathy"},{"rate":null,"effect":"Hyperamylasemia"},{"rate":null,"effect":"Acute kidney injury"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gelaspan is a modified fluid gelatin (succinylated gelatin) that functions as a colloid to expand intravascular volume and improve tissue perfusion. It remains in the vascular space longer than crystalloid solutions, providing sustained hemodynamic support. It is used as a blood substitute or plasma expander in acute blood loss and hypovolemic shock situations.","oneSentence":"Gelaspan 4% is a gelatin-based plasma volume expander that increases and maintains circulating blood volume through colloidal osmotic pressure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:13:51.143Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute blood loss and hypovolemic shock requiring volume replacement"},{"name":"Perioperative volume management"}]},"trialDetails":[{"nctId":"NCT07172451","phase":"PHASE4","title":"Gelaspan vs Crystalloid Therapy in Sepsis","status":"RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2026-02-13","conditions":"Sepsis, Intra-Abdominal Infections","enrollment":318},{"nctId":"NCT02495285","phase":"","title":"Gelatines in Pediatric PatientS","status":"COMPLETED","sponsor":"B. Braun Melsungen AG","startDate":"2015-05","conditions":"Treatment of Hypovolemia and Shock","enrollment":601},{"nctId":"NCT02808325","phase":"PHASE3","title":"Study on the Efficacy and Safety of Gelaspan","status":"COMPLETED","sponsor":"B. Braun Medical LLC","startDate":"2016-06","conditions":"Hypovolemia","enrollment":72}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Gelaspan 4%","genericName":"Gelaspan 4%","companyName":"B. Braun Melsungen AG","companyId":"b-braun-melsungen-ag","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gelaspan 4% is a gelatin-based plasma volume expander that increases and maintains circulating blood volume through colloidal osmotic pressure. Used for Acute blood loss and hypovolemic shock requiring volume replacement, Perioperative volume management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}