{"id":"ganirelix-0-25-mg","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Injection site reactions (erythema, bruising, pain)"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Abdominal pain"},{"rate":"3-8","effect":"Nausea"},{"rate":"1-5","effect":"Ovarian hyperstimulation syndrome (OHSS)"}]},"_chembl":{"chemblId":"CHEMBL1251","moleculeType":"Protein","molecularWeight":"1570.35"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ganirelix competitively binds to GnRH receptors in the pituitary gland, rapidly blocking the release of LH and FSH without an initial surge. This prevents the natural LH surge that would trigger ovulation prematurely, allowing controlled ovarian stimulation and egg retrieval in fertility treatment cycles. The drug provides immediate suppression without the flare effect seen with GnRH agonists.","oneSentence":"Ganirelix is a gonadotropin-releasing hormone (GnRH) antagonist that suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to prevent premature ovulation during assisted reproductive procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:47:12.075Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (ART) procedures"}]},"trialDetails":[{"nctId":"NCT04983173","phase":"PHASE4","title":"INTEnsity of ovariaN Stimulation and Embryo Quality","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2021-11-23","conditions":"Infertility","enrollment":110},{"nctId":"NCT07409493","phase":"NA","title":"IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols","status":"RECRUITING","sponsor":"Hanoi Medical University","startDate":"2026-01-21","conditions":"Infertility (IVF Patients), Embryo Morphokinetics, Progestins Primed Ovarian Stimulation","enrollment":148},{"nctId":"NCT05847283","phase":"NA","title":"DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT","status":"RECRUITING","sponsor":"Tam Anh TP. 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gonadotropin-releasing hormone (GnRH) antagonist that suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to prevent premature ovulation during assisted reproductive procedures. Used for Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (ART) procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}