{"id":"gamma-interferon-1b","brandName":"Gamma Interferon 1b","genericName":"Gamma Interferon 1b","companyId":"national-institute-of-diabetes-and-digestive-and-kidney-diseases-niddk","companyName":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Gamma Interferon 1b is an investigational immunomodulatory agent with multiple ongoing clinical trials for various conditions, including fungal infections, cancer, and genetic disorders. Despite no FDA approval, it shows promise in Phase 2 studies for candidemia and mycosis fungoides.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"IFN-γ-1b is a recombinant cytokine that binds to interferon-gamma receptors on immune cells, particularly macrophages, enhancing their antimicrobial and antitumor activity. It increases expression of MHC molecules and activates natural killer cells and T cells, strengthening both innate and adaptive immune responses. This mechanism makes it useful in conditions characterized by impaired immune function or chronic infections.","oneSentence":"Gamma Interferon 1b (IFN-γ-1b) activates macrophages and enhances immune cell function to boost innate and adaptive immunity.","_ai_confidence":"medium"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Injection site reactions"}]},"trials":[],"indications":{"approved":[{"name":"Chronic granulomatous disease (CGD)"},{"name":"Severe osteopetrosis"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}