{"id":"gadoterate-dotarem-clariscan","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Nephrogenic systemic fibrosis (rare, in severe renal impairment)"}]},"_chembl":{"chemblId":"CHEMBL2219415","moleculeType":"Small molecule","molecularWeight":"753.86"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gadoterate is a macrocyclic gadolinium chelate complex that distributes into the extracellular space following intravenous injection. The paramagnetic gadolinium ion shortens T1 and T2 relaxation times of nearby water protons, producing bright signal enhancement on T1-weighted MRI images. This allows improved delineation of tissues, blood vessels, and pathological lesions with altered perfusion or permeability.","oneSentence":"Gadoterate is a gadolinium-based contrast agent that accumulates in tissues and enhances MRI signal to improve visualization of anatomical structures and lesions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:31:01.735Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"MRI contrast enhancement for central nervous system imaging"},{"name":"MRI contrast enhancement for body imaging including cardiovascular and abdominal applications"}]},"trialDetails":[{"nctId":"NCT03602339","phase":"PHASE4","title":"Comparison of Gadovist 75% Standard Dose to Dotarem at Full Standard Dose","status":"COMPLETED","sponsor":"Bayer","startDate":"2018-11-14","conditions":"Magnetic Resonance Imaging","enrollment":157}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Gadoterate"],"phase":"marketed","status":"active","brandName":"Gadoterate (Dotarem/Clariscan)","genericName":"Gadoterate (Dotarem/Clariscan)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gadoterate is a gadolinium-based contrast agent that accumulates in tissues and enhances MRI signal to improve visualization of anatomical structures and lesions. Used for MRI contrast enhancement for central nervous system imaging, MRI contrast enhancement for body imaging including cardiovascular and abdominal applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}