{"id":"gadoquatrane-bay1747846","safety":{"commonSideEffects":[{"rate":null,"effect":"Gadolinium retention in tissues"},{"rate":null,"effect":"Nephrogenic systemic fibrosis (NSF) risk in renal impairment"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gadoquatrane (BAY1747846) is a macrocyclic gadolinium chelate contrast agent that works by shortening the T1 relaxation time of water protons in tissues, thereby increasing signal intensity on T1-weighted MRI images. It is formulated as a blood pool agent intended to provide prolonged vascular enhancement, enabling improved imaging of perfusion and vascular anatomy.","oneSentence":"Gadoquatrane is a gadolinium-based contrast agent designed for magnetic resonance imaging (MRI) that provides enhanced visualization of blood vessels and tissues.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:13:42.136Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Magnetic resonance imaging (MRI) contrast enhancement for vascular and tissue imaging"}]},"trialDetails":[{"nctId":"NCT05915728","phase":"PHASE3","title":"A Study to Compare How Well Gadoquatrane Works and Its Safety With an Already Available Contrast Agent for MRI in People With Any Known or Suspected Problems of the Body (Except Brain or Spinal Cord-related Problems)","status":"COMPLETED","sponsor":"Bayer","startDate":"2023-07-24","conditions":"Contrast Enhancement in Magnetic Resonance Imaging, Non-central Nervous System Pathology","enrollment":404},{"nctId":"NCT05915702","phase":"PHASE3","title":"A Study to Compare How Well Gadoquatrane Works and Its Safety With an Already Available Contrast Agent for MRI in People With Known or Suspected Brain or Spinal Cord-related Problems","status":"COMPLETED","sponsor":"Bayer","startDate":"2023-07-24","conditions":"Contrast Enhancement in Magnetic Resonance Imaging, Central Nervous System Pathology","enrollment":303},{"nctId":"NCT05915026","phase":"PHASE3","title":"A Study to Learn How Gadoquatrane Moves Into, Through, and Out of the Body and How Safe it is in Children (From Birth to <18 Years), Who Will Undergo a Contrast Enhanced MRI (Quanti Pediatric)","status":"COMPLETED","sponsor":"Bayer","startDate":"2023-08-16","conditions":"Contrast Enhancement in Magnetic Resonance Imaging, Children","enrollment":93},{"nctId":"NCT06135181","phase":"PHASE1","title":"A Study to Learn More About the Safety and the Blood Level of BAY1747846 Given as Injection Into the Vein at Increasing Single Doses in Chinese Healthy Male Participants","status":"COMPLETED","sponsor":"Bayer","startDate":"2020-08-26","conditions":"Contrast Enhancement in Magnetic Resonance Imaging, Healthy Volunteers","enrollment":24},{"nctId":"NCT04307186","phase":"PHASE2","title":"Study to Find the Appropriate Dose of a New Gadolinium-based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Brain and/or Spinal Cord Conditions","status":"COMPLETED","sponsor":"Bayer","startDate":"2020-11-18","conditions":"Central Nervous System Pathology","enrollment":57}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Gadoquatrane (BAY1747846)","genericName":"Gadoquatrane (BAY1747846)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gadoquatrane is a gadolinium-based contrast agent designed for magnetic resonance imaging (MRI) that provides enhanced visualization of blood vessels and tissues. Used for Magnetic resonance imaging (MRI) contrast enhancement for vascular and tissue imaging.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}