{"id":"gadopentetate-dimeglumine-0-05-mmol","safety":{"commonSideEffects":[{"rate":null,"effect":"Gadolinium retention in tissues"},{"rate":"rare","effect":"Nephrogenic systemic fibrosis (NSF) in patients with severe renal impairment"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1200431","moleculeType":"Small molecule","molecularWeight":"742.79"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gadopentetate dimeglumine is a paramagnetic gadolinium chelate complex that distributes in extracellular fluid and is taken up by tissues with increased vascularity or altered blood-brain barrier permeability. The gadolinium ion enhances MRI contrast by altering the relaxation properties of nearby water protons, improving visualization of anatomical structures and pathological lesions. The dimeglumine salt formulation improves solubility and safety by chelating the gadolinium ion.","oneSentence":"Gadopentetate dimeglumine is a gadolinium-based contrast agent that accumulates in tissues and enhances magnetic resonance imaging (MRI) signal by shortening T1 relaxation time.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:51.670Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"MRI contrast enhancement for central nervous system imaging"},{"name":"MRI contrast enhancement for body imaging including cardiovascular and abdominal applications"}]},"trialDetails":[{"nctId":"NCT02633501","phase":"PHASE2","title":"P03277 Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)","status":"COMPLETED","sponsor":"Guerbet","startDate":"2016-06","conditions":"CNS Lesion, Blood Brain Barrier Defect","enrollment":312},{"nctId":"NCT03147989","phase":"","title":"Retrospective Study of MRI With MULTIHANCE at 0.10 and 0.05 mmol/Kg Dose in CNS Patients","status":"COMPLETED","sponsor":"Bracco Diagnostics, Inc","startDate":"2017-05-18","conditions":"Central Nervous System Diseases, Central Nervous System Neoplasms","enrollment":352},{"nctId":"NCT02070380","phase":"PHASE4","title":"Crossover Comparison of MultiHance and Dotarem","status":"COMPLETED","sponsor":"Bracco Diagnostics, Inc","startDate":"2014-02","conditions":"Brain Disease","enrollment":179},{"nctId":"NCT00937391","phase":"PHASE3","title":"Contrast-enhanced MRI in Children 2 Months to <2 Years","status":"COMPLETED","sponsor":"Bayer","startDate":"2010-01","conditions":"Magnetic Resonance Imaging","enrollment":54},{"nctId":"NCT02175069","phase":"PHASE4","title":"Magnetic Resonance Imaging of Interscalene Plexus Block","status":"COMPLETED","sponsor":"Paracelsus Medical University","startDate":"2013-12","conditions":"Disorder of Shoulder","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Magnevist"],"phase":"marketed","status":"active","brandName":"Gadopentetate-Dimeglumine 0.05 mmol","genericName":"Gadopentetate-Dimeglumine 0.05 mmol","companyName":"Paracelsus Medical University","companyId":"paracelsus-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gadopentetate dimeglumine is a gadolinium-based contrast agent that accumulates in tissues and enhances magnetic resonance imaging (MRI) signal by shortening T1 relaxation time. Used for MRI contrast enhancement for central nervous system imaging, MRI contrast enhancement for body imaging including cardiovascular and abdominal applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}