{"id":"gadopentetate-dimeglumine-0-0125-mmol","safety":{"commonSideEffects":[{"rate":null,"effect":"Gadolinium retention in tissues"},{"rate":null,"effect":"Nephrogenic systemic fibrosis (NSF) in patients with severe renal impairment"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL1200431","moleculeType":"Small molecule","molecularWeight":"742.79"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gadopentetate dimeglumine is a paramagnetic gadolinium chelate complex that distributes into the extracellular space following intravenous administration. The gadolinium ion shortens the T1 relaxation time of nearby water molecules, resulting in increased signal intensity on T1-weighted MRI images. This enhancement allows improved visualization and characterization of tissues and lesions during diagnostic MRI procedures.","oneSentence":"Gadopentetate dimeglumine is a gadolinium-based contrast agent that accumulates in tissues and enhances magnetic resonance imaging (MRI) signal by altering the relaxation properties of water protons.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:51.318Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"MRI contrast enhancement for central nervous system imaging"},{"name":"MRI contrast enhancement for body imaging including liver, kidney, and other organs"}]},"trialDetails":[{"nctId":"NCT02175069","phase":"PHASE4","title":"Magnetic Resonance Imaging of Interscalene Plexus Block","status":"COMPLETED","sponsor":"Paracelsus Medical University","startDate":"2013-12","conditions":"Disorder of Shoulder","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Magnevist"],"phase":"marketed","status":"active","brandName":"Gadopentetate-Dimeglumine 0.0125 mmol","genericName":"Gadopentetate-Dimeglumine 0.0125 mmol","companyName":"Paracelsus Medical University","companyId":"paracelsus-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gadopentetate dimeglumine is a gadolinium-based contrast agent that accumulates in tissues and enhances magnetic resonance imaging (MRI) signal by altering the relaxation properties of water protons. Used for MRI contrast enhancement for central nervous system imaging, MRI contrast enhancement for body imaging including liver, kidney, and other organs.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}