{"id":"gabapentin-etoricoxib-sugar-pill","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Dizziness"},{"rate":"10-15","effect":"Somnolence"},{"rate":"5-10","effect":"Peripheral edema"},{"rate":"5-10","effect":"Gastrointestinal upset"},{"rate":"5-10","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL940","moleculeType":"Small molecule","molecularWeight":"171.24"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters and thereby decreasing neuropathic pain signaling. Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of pro-inflammatory prostaglandins and providing analgesic and anti-inflammatory effects. The sugar pill serves as a placebo control component.","oneSentence":"This is a combination product containing gabapentin (a gabapentinoid that modulates calcium channels to reduce neuronal excitability), etoricoxib (a selective COX-2 inhibitor that reduces prostaglandin-mediated inflammation and pain), and a placebo control.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:39:51.403Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain (gabapentin component)"},{"name":"Inflammatory pain and osteoarthritis (etoricoxib component)"}]},"trialDetails":[{"nctId":"NCT00799149","phase":"PHASE4","title":"Etoricoxib Versus Gabapentin for Knee Arthroscopy","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2006-06","conditions":"Knee Arthroscopy","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Gabapentin, Etoricoxib, Sugar pill","genericName":"Gabapentin, Etoricoxib, Sugar pill","companyName":"Meir Medical Center","companyId":"meir-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination product containing gabapentin (a gabapentinoid that modulates calcium channels to reduce neuronal excitability), etoricoxib (a selective COX-2 inhibitor that reduces prostaglandin-mediated inflammation and pain), and a placebo control. Used for Neuropathic pain (gabapentin component), Inflammatory pain and osteoarthritis (etoricoxib component).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}