{"id":"g17dt-irinotecan","safety":{"commonSideEffects":[{"rate":"30-50%","effect":"Diarrhea"},{"rate":"20-40%","effect":"Fatigue"},{"rate":"20-40%","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL3989514","moleculeType":"Small molecule","molecularWeight":"677.19"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This mechanism of action is similar to that of irinotecan, a well-known chemotherapeutic agent. By inhibiting topoisomerase I, G17DT-Irinotecan prevents cancer cells from replicating and ultimately leads to cell death.","oneSentence":"G17DT-Irinotecan is a topoisomerase I inhibitor, which works by blocking the enzyme topoisomerase I and preventing DNA replication in cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:33:31.336Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic colorectal cancer"}]},"trialDetails":[{"nctId":"NCT02118064","phase":"PHASE2","title":"Phase II Study to Evaluate G17DT in Combination With Irinotecan in Patients With Colorectal Carcinoma","status":"COMPLETED","sponsor":"Cancer Advances Inc.","startDate":"2001-03","conditions":"Colorectal Cancer","enrollment":161}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"G17DT-Irinotecan","genericName":"G17DT-Irinotecan","companyName":"Cancer Advances Inc.","companyId":"cancer-advances-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"G17DT-Irinotecan is a topoisomerase I inhibitor, which works by blocking the enzyme topoisomerase I and preventing DNA replication in cancer cells. Used for Metastatic colorectal cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}