{"id":"furtrethonium","rwe":[{"pmid":"8882897","year":"1995","title":"Cholinergic agents structurally related to furtrethonium. 3. Synthesis and antimuscarinic activity of a series of N-(5-methyl-2-furfuryl and-tiophenyl)-dialkyl amines and of 2-dimethylamino methyl-4-(1'-substituted-acetoxy-methyl)-1,3-dioxolanes.","finding":"","journal":"Drug design and discovery","studyType":"Clinical Study"},{"pmid":"7996539","year":"1994","title":"Cholinergic agents structurally related to furtrethonium. 2. Synthesis and antimuscarinic activity of a series of N-[5-[(1'-substituted-acetoxy) methyl]-2-furfuryl]dialkylamines.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"1919416","year":"1991","title":"The pharmacology of cholinoceptors on the somatic muscle cells of the parasitic nematode Ascaris suum.","finding":"","journal":"The Journal of experimental biology","studyType":"Clinical Study"},{"pmid":"2615370","year":"1989","title":"Characterization of the rabbit aorta endothelium-dependent cholinergic receptor by agonist equipotent molar doses.","finding":"","journal":"Journal of pharmacological methods","studyType":"Clinical Study"},{"pmid":"3669908","year":"1987","title":"The effect of propylbenzilylcholine mustard on contraction and radioligand binding parameters of muscarinic receptors in guinea pig ileum.","finding":"","journal":"Life sciences","studyType":"Clinical Study"}],"tags":[{"label":"furtrethonium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Muscarinic acetylcholine receptor M2","category":"target"},{"label":"CHRM2","category":"gene"},{"label":"CHRM4","category":"gene"},{"label":"CHRM1","category":"gene"},{"label":"Active","category":"status"},{"label":"Cholinergic Agents","category":"pharmacology"},{"label":"Cholinergic Agonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"furmethide","offLabel":[],"synonyms":["furtrethonium chloride","furmethide","furtrethonium","furfuryltrimethylammonium","furtretonium","furtrimethonium","furtrethonium iodide"],"timeline":[],"aiSummary":"Furmethide is a small molecule with the synonyms FURAMON, FURMETHIDE IODIDE, FURTRETHONIUM IODIDE, IODURE DE FURTRETHONIUM, IODURO DE FURTRETONIO, and NSC-27126. Its modality is classified as a small molecule.","approvals":[],"brandName":"Furmethide","ecosystem":[],"mechanism":{"target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","targets":[{"gene":"CHRM2","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M2","protein":"Muscarinic acetylcholine receptor M2"},{"gene":"CHRM4","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M4","protein":"Muscarinic acetylcholine receptor M4"},{"gene":"CHRM1","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M1","protein":"Muscarinic acetylcholine receptor M1"},{"gene":"CHRM3","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M3","protein":"Muscarinic acetylcholine receptor M3"}],"modality":"Small Molecule","drugClass":"furtrethonium","explanation":"Think of acetylcholine as a key that unlocks a door in your body. The muscarinic acetylcholine receptor M2 is like a lock on that door. When furmethide blocks this lock, it prevents acetylcholine from doing its job, which can affect various bodily functions.","oneSentence":"Furmethide works by blocking the action of acetylcholine at the muscarinic acetylcholine receptor M2.","technicalDetail":"Furmethide acts as a competitive antagonist at the M2 muscarinic acetylcholine receptor, inhibiting the binding of acetylcholine and thereby modulating parasympathetic neurotransmission."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3256","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FURTRETHONIUM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:39:47.733797","biosimilars":[],"competitors":[{"drugName":"acetylcholine","drugSlug":"acetylcholine","fdaApproval":"1973-10-09","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"aclidinium bromide","drugSlug":"aclidinium-bromide","fdaApproval":"2012-07-23","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amoxapine","drugSlug":"amoxapine","fdaApproval":"1980-09-22","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"atropine","drugSlug":"atropine","fdaApproval":"1960-09-15","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"azelastine","drugSlug":"azelastine","fdaApproval":"1996-11-01","patentExpiry":"Jun 4, 2028","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"furtrethonium","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetylcholine","brandName":"acetylcholine","genericName":"acetylcholine","approvalYear":"1973","relationship":"same-target"},{"drugId":"aclidinium-bromide","brandName":"aclidinium bromide","genericName":"aclidinium bromide","approvalYear":"2012","relationship":"same-target"},{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-target"},{"drugId":"amitriptyline","brandName":"amitriptyline","genericName":"amitriptyline","approvalYear":"1961","relationship":"same-target"},{"drugId":"amoxapine","brandName":"amoxapine","genericName":"amoxapine","approvalYear":"1980","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"},{"drugId":"atropine","brandName":"atropine","genericName":"atropine","approvalYear":"1960","relationship":"same-target"},{"drugId":"azelastine","brandName":"azelastine","genericName":"azelastine","approvalYear":"1996","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"AIQ630U6XO","CHEBI":"CHEBI:134764","INN_ID":"133","UMLSCUI":"C0060876","ChEMBL_ID":"CHEMBL2110739","PUBCHEM_CID":"10938","IUPHAR_LIGAND_ID":"299","SECONDARY_CAS_RN":"6035-90-1","MESH_SUPPLEMENTAL_RECORD_UI":"C028530"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"1995 Aug","pmid":"8882897","title":"Cholinergic agents structurally related to furtrethonium. 3. Synthesis and antimuscarinic activity of a series of N-(5-methyl-2-furfuryl and-tiophenyl)-dialkyl amines and of 2-dimethylamino methyl-4-(1'-substituted-acetoxy-methyl)-1,3-dioxolanes.","journal":"Drug design and discovery"},{"date":"1994 Dec 9","pmid":"7996539","title":"Cholinergic agents structurally related to furtrethonium. 2. Synthesis and antimuscarinic activity of a series of N-[5-[(1'-substituted-acetoxy) methyl]-2-furfuryl]dialkylamines.","journal":"Journal of medicinal chemistry"},{"date":"1991 Jul","pmid":"1919416","title":"The pharmacology of cholinoceptors on the somatic muscle cells of the parasitic nematode Ascaris suum.","journal":"The Journal of experimental biology"},{"date":"1989 Dec","pmid":"2615370","title":"Characterization of the rabbit aorta endothelium-dependent cholinergic receptor by agonist equipotent molar doses.","journal":"Journal of pharmacological methods"},{"date":"1987 Oct 26","pmid":"3669908","title":"The effect of propylbenzilylcholine mustard on contraction and radioligand binding parameters of muscarinic receptors in guinea pig ileum.","journal":"Life sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}