{"id":"furosemide-plus-chlorothiazide","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Ototoxicity (with high-dose furosemide)"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hypotension"}]},"_chembl":{"chemblId":"CHEMBL842","moleculeType":"Small molecule","molecularWeight":"295.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Furosemide is a loop diuretic that blocks the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, while chlorothiazide is a thiazide diuretic that inhibits the Na-Cl cotransporter in the distal convoluted tubule. Together, they provide synergistic diuretic and natriuretic effects, reducing blood volume and intracellular/extracellular fluid accumulation. This combination is used in resistant hypertension or severe edema where monotherapy is insufficient.","oneSentence":"This combination of two loop and thiazide diuretics works by inhibiting sodium and chloride reabsorption in the kidney to increase urine output and reduce fluid overload.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:46:54.422Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema and fluid overload in heart failure, renal disease, or hepatic cirrhosis"},{"name":"Resistant hypertension"}]},"trialDetails":[{"nctId":"NCT07469722","phase":"PHASE2, PHASE3","title":"POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure","status":"NOT_YET_RECRUITING","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2026-03-23","conditions":"Acute Heart Failure (AHF), Congestive Heart Failure Acute, Diuretic Effect","enrollment":128},{"nctId":"NCT03511118","phase":"","title":"Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants","status":"RECRUITING","sponsor":"Duke University","startDate":"2018-10-04","conditions":"Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI","enrollment":1600},{"nctId":"NCT03892148","phase":"PHASE4","title":"Protocol of Diuretics Use in Congestive Therapy in Heart Failure","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2019-05-17","conditions":"Heart Failure, Acute Heart Failure, Chronic Heart Failure","enrollment":299},{"nctId":"NCT05171686","phase":"PHASE4","title":"Diuretics and Volume Overload in Early CKD","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2023-02-01","conditions":"Chronic Kidney Disease, Hypertension","enrollment":49},{"nctId":"NCT02546583","phase":"PHASE1","title":"Diagnosing and Targeting Mechanisms of Diuretic Resistance in Heart Failure","status":"COMPLETED","sponsor":"Yale University","startDate":"2015-08-31","conditions":"Heart Failure","enrollment":458},{"nctId":"NCT06362668","phase":"NA","title":"EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System (FASTR-EU)","status":"COMPLETED","sponsor":"Reprieve Cardiovascular, Inc","startDate":"2024-05-17","conditions":"Acute Decompensated Heart Failure","enrollment":12},{"nctId":"NCT00690521","phase":"NA","title":"A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients","status":"COMPLETED","sponsor":"University of New Mexico","startDate":"2004-10-26","conditions":"Congestive Heart Failure","enrollment":8},{"nctId":"NCT05840536","phase":"PHASE4","title":"Combination Diuretic Therapy for Acute Decompensated Heart Failure","status":"WITHDRAWN","sponsor":"Ochsner Health System","startDate":"2014-05","conditions":"Acute Decompensated Heart Failure","enrollment":""},{"nctId":"NCT04467931","phase":"","title":"ACEI or ARB and COVID-19 Severity and Mortality in US Veterans","status":"COMPLETED","sponsor":"University of Utah","startDate":"2020-01-19","conditions":"Hypertension, COVID","enrollment":22213},{"nctId":"NCT02765009","phase":"NA","title":"Effects of Fluid Balance Control in Critically Ill Patients","status":"COMPLETED","sponsor":"Central Hospital, Nancy, France","startDate":"2016-06-01","conditions":"Fluid Shifts, Critical Care","enrollment":1411},{"nctId":"NCT04465123","phase":"PHASE3","title":"Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study","status":"UNKNOWN","sponsor":"Chiang Mai University","startDate":"2020-08-13","conditions":"Acute Heart Failure, Acute Kidney Injury","enrollment":100},{"nctId":"NCT01921829","phase":"PHASE4","title":"Protocolized Diuretic Strategy in Cardiorenal Failure","status":"TERMINATED","sponsor":"Kelly V. Liang, MD","startDate":"2013-11","conditions":"Cardiac Failure, Renal Failure, Kidney Failure","enrollment":19},{"nctId":"NCT01721655","phase":"PHASE2, PHASE3","title":"Determining the Effect of Spironolactone on Electrolyte Supplementation in Preterm Infants With Chronic Lung Disease","status":"UNKNOWN","sponsor":"West Virginia University Healthcare","startDate":"2012-10","conditions":"Chronic Lung Disease, Bronchopulmonary Dysplasia","enrollment":40},{"nctId":"NCT00000620","phase":"PHASE3","title":"Action to Control Cardiovascular Risk in Diabetes (ACCORD)","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"1999-09","conditions":"Atherosclerosis, Cardiovascular Diseases, Hypercholesterolemia","enrollment":10251},{"nctId":"NCT00306696","phase":"PHASE4","title":"Examining the Effect of Different Diuretics on Fluid Retention in Diabetics Treated With Rosiglitazone.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2002-10","conditions":"Diabetes Mellitus","enrollment":388},{"nctId":"NCT01977430","phase":"PHASE4","title":"Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function","status":"UNKNOWN","sponsor":"Corporacion Parc Tauli","startDate":"2013-11","conditions":"Chronic Kidney Insufficiency, Hemodialysis Treatment, Diuresis Preserved","enrollment":36},{"nctId":"NCT00671424","phase":"PHASE1","title":"A Study To Compare Effects Of GSK189075 In Combination With Either Furosemide Or Hydrochlorothiazide","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-03","conditions":"Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lasix plus Diuril"],"phase":"marketed","status":"active","brandName":"Furosemide plus Chlorothiazide","genericName":"Furosemide plus Chlorothiazide","companyName":"Ochsner Health System","companyId":"ochsner-health-system","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination of two loop and thiazide diuretics works by inhibiting sodium and chloride reabsorption in the kidney to increase urine output and reduce fluid overload. Used for Edema and fluid overload in heart failure, renal disease, or hepatic cirrhosis, Resistant hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}