{"id":"furosemide-diuretic","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Ototoxicity (at high doses)"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hyponatremia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Furosemide is a loop diuretic that blocks the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, preventing reabsorption of sodium, potassium, and chloride. This increases osmotic pressure in the tubular lumen, reducing water reabsorption and leading to increased urine output. The drug is highly potent due to its site of action in the loop of Henle, which normally reabsorbs 25-30% of filtered sodium.","oneSentence":"Furosemide inhibits sodium and chloride reabsorption in the thick ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:30:56.649Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema associated with congestive heart failure"},{"name":"Edema associated with hepatic cirrhosis"},{"name":"Edema associated with renal disease"},{"name":"Hypertension"},{"name":"Pulmonary edema"}]},"trialDetails":[{"nctId":"NCT06094816","phase":"PHASE4","title":"Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study","status":"RECRUITING","sponsor":"University of Delaware","startDate":"2024-03-05","conditions":"Salt-Sensitivity of Blood Pressure","enrollment":120},{"nctId":"NCT07469722","phase":"PHASE2, PHASE3","title":"POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure","status":"NOT_YET_RECRUITING","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2026-03-23","conditions":"Acute Heart Failure (AHF), Congestive Heart Failure Acute, Diuretic Effect","enrollment":128},{"nctId":"NCT05305495","phase":"PHASE4","title":"Empagliflozin in Acute Heart Failure","status":"COMPLETED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2022-12-22","conditions":"Acute Heart Failure, Chronic Kidney Diseases","enrollment":25},{"nctId":"NCT07464249","phase":"NA","title":"Comparison of the Effectiveness of Different Diuretic Therapies in the Management of Acute Heart Failure","status":"COMPLETED","sponsor":"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey","startDate":"2024-04-03","conditions":"Acute Decompensated Heart Failure (ADHF)","enrollment":50},{"nctId":"NCT06995144","phase":"PHASE4","title":"Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure","status":"COMPLETED","sponsor":"Sarfez Pharmaceuticals, Inc.","startDate":"2025-05-28","conditions":"Heart Failure, Edema, Pulmonary Congestion","enrollment":20},{"nctId":"NCT07223502","phase":"PHASE3","title":"A Study Comparing the Clinical Benefit of Finerenone Versus a Fixed Dose Combination (FDC) of Extended-Release Torsemide and Spironolactone in Patients With Hypertension and Chronic Kidney Disease","status":"RECRUITING","sponsor":"Sarfez Pharmaceuticals, Inc.","startDate":"2025-12-01","conditions":"Hypertension (HTN)","enrollment":30},{"nctId":"NCT07422948","phase":"NA","title":"Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure.","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2026-02-05","conditions":"Acute on Chronic Liver Failure","enrollment":113},{"nctId":"NCT07417969","phase":"NA","title":"\"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function\"","status":"RECRUITING","sponsor":"Jose J Zaragoza, MD MSc","startDate":"2025-06-01","conditions":"Urine Output Decreased","enrollment":56},{"nctId":"NCT06921603","phase":"NA","title":"POCUS-Guided Diuresis for Decompensated Heart Failure","status":"RECRUITING","sponsor":"University of Pittsburgh","startDate":"2025-06-29","conditions":"Heart Decompensation, Acute, Acute Kidney Injuries","enrollment":588},{"nctId":"NCT06272734","phase":"NA","title":"Reprieve System Pilot Study","status":"RECRUITING","sponsor":"Reprieve Cardiovascular, Inc","startDate":"2024-01-23","conditions":"Acute Decompensated Heart Failure","enrollment":50},{"nctId":"NCT03892148","phase":"PHASE4","title":"Protocol of Diuretics Use in Congestive Therapy in Heart Failure","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2019-05-17","conditions":"Heart Failure, Acute Heart Failure, Chronic Heart Failure","enrollment":299},{"nctId":"NCT07167862","phase":"PHASE4","title":"Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound","status":"NOT_YET_RECRUITING","sponsor":"University of California, Irvine","startDate":"2026-06-15","conditions":"Preeclampsia, Preeclampsia Postpartum, Preeclampsia Severe or Mild","enrollment":96},{"nctId":"NCT07077772","phase":"NA","title":"Natriuresis-guided Depletion After Cardiac Surgery","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2025-06-25","conditions":"Cardiac Surgery, Diuresis, Congestion, Venous","enrollment":102},{"nctId":"NCT07348510","phase":"NA","title":"Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-01-17","conditions":"Diuretic Effect, Aminophylline, Furosemide","enrollment":106},{"nctId":"NCT06036914","phase":"PHASE2","title":"A Study of Ultra High Dose Diuretics to Treat Heart Failure","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2023-11-27","conditions":"Heart Failure; With Decompensation","enrollment":20},{"nctId":"NCT07335900","phase":"NA","title":"A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis","status":"RECRUITING","sponsor":"RenJi Hospital","startDate":"2025-12-19","conditions":"Severe Aortic Valve Stenosis","enrollment":25},{"nctId":"NCT07336485","phase":"NA","title":"Forced Diuresis After Flexible Ureteroscopy for Medium-Sized Renal Stones","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2025-01-01","conditions":"Kidney Stones","enrollment":2000},{"nctId":"NCT05898022","phase":"PHASE4","title":"Pragmatic Research on Diuretic Management in Early BPD Pilot","status":"COMPLETED","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2023-08-17","conditions":"Bronchopulmonary Dysplasia","enrollment":19},{"nctId":"NCT06285760","phase":"","title":"Effect of Acetazolamide on Diuresis and Natriuresis in Patients With Acute Heart Failure (SANDI STUDY)","status":"RECRUITING","sponsor":"Puerta de Hierro University Hospital","startDate":"2024-03-01","conditions":"Heart Failure, Persistent Congestion","enrollment":64},{"nctId":"NCT05171686","phase":"PHASE4","title":"Diuretics and Volume Overload in Early CKD","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2023-02-01","conditions":"Chronic Kidney Disease, Hypertension","enrollment":49},{"nctId":"NCT07263035","phase":"PHASE4","title":"Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure","status":"NOT_YET_RECRUITING","sponsor":"Lakeland Regional Health Systems, Inc.","startDate":"2026-01-01","conditions":"Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Acute","enrollment":600},{"nctId":"NCT06898515","phase":"PHASE3","title":"Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)","status":"RECRUITING","sponsor":"Reprieve Cardiovascular, Inc","startDate":"2025-07-14","conditions":"Acute Decompensated Heart Failure","enrollment":400},{"nctId":"NCT03296813","phase":"PHASE3","title":"TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure","status":"COMPLETED","sponsor":"Duke University","startDate":"2018-07-11","conditions":"Heart Failure","enrollment":2973},{"nctId":"NCT07199088","phase":"NA","title":"Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure","status":"RECRUITING","sponsor":"University of Health Sciences Lahore","startDate":"2025-10-11","conditions":"Acute Decompensated Heart Failure, Heart Failure, Diastolic, Heart Failure, Systolic","enrollment":320},{"nctId":"NCT04216784","phase":"PHASE4","title":"Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients","status":"TERMINATED","sponsor":"Rush University Medical Center","startDate":"2019-12-19","conditions":"Cirrhosis, Liver, Volume Overload, Fluid Overload","enrollment":21},{"nctId":"NCT07076615","phase":"PHASE4","title":"The Effect of Dapagliflozin on Patients With Cardiomyopathy","status":"RECRUITING","sponsor":"May Mohamed Abdalla","startDate":"2025-08","conditions":"Acute Decompensated Heart Failure (ADHF)","enrollment":100},{"nctId":"NCT02546583","phase":"PHASE1","title":"Diagnosing and Targeting Mechanisms of Diuretic Resistance in Heart Failure","status":"COMPLETED","sponsor":"Yale University","startDate":"2015-08-31","conditions":"Heart Failure","enrollment":458},{"nctId":"NCT07099885","phase":"NA","title":"Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure","status":"RECRUITING","sponsor":"Wroclaw Medical University","startDate":"2025-08-01","conditions":"Acute Heart Failure (AHF), Congestion, Venous","enrollment":90},{"nctId":"NCT02638142","phase":"","title":"Loop Diuretic Therapy in Acutely Decompensated Heart Failure","status":"RECRUITING","sponsor":"University of Siena","startDate":"2015-12","conditions":"Acute Heart Failure","enrollment":370},{"nctId":"NCT06092437","phase":"NA","title":"Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients","status":"RECRUITING","sponsor":"Zuyderland Medisch Centrum","startDate":"2023-02-27","conditions":"Heart Failure Acute","enrollment":466},{"nctId":"NCT05174312","phase":"NA","title":"Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)","status":"COMPLETED","sponsor":"Reprieve Cardiovascular, Inc","startDate":"2022-07-11","conditions":"Acute Decompensated Heart Failure","enrollment":100},{"nctId":"NCT05528588","phase":"PHASE2","title":"Furoscix in Heart Failure Patients With Diuretic Resistance","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2023-06-02","conditions":"Heart Failure","enrollment":70},{"nctId":"NCT07008365","phase":"PHASE3","title":"The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure","status":"RECRUITING","sponsor":"Instituto de Investigación Sanitaria Aragón","startDate":"2025-03-10","conditions":"Acute Heart Failure, Congestive Heart Failure, Intraabdominal Hypertension","enrollment":168},{"nctId":"NCT04201704","phase":"NA","title":"Effect of Giving Reduced Fluid in Children After Trauma","status":"RECRUITING","sponsor":"Columbia University","startDate":"2018-08-27","conditions":"Critical Illness, Pediatrics, General Surgery","enrollment":250},{"nctId":"NCT05419115","phase":"PHASE2","title":"Use of a Novel SUBCUTaneous Preparation of Furosemide to Facilitate Early Supported Discharge of Patients With Heart Failure","status":"RECRUITING","sponsor":"NHS Greater Glasgow and Clyde","startDate":"2022-11-17","conditions":"Heart Failure","enrollment":170},{"nctId":"NCT06251713","phase":"NA","title":"Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2024-07-31","conditions":"Acute Kidney Injury, Cardiac Surgery, Venous Congestion","enrollment":40},{"nctId":"NCT05915286","phase":"PHASE4","title":"Diuretic Use in Hemodialysis Patients With Residual Renal Function","status":"SUSPENDED","sponsor":"University of Alberta","startDate":"2023-05-29","conditions":"End Stage Renal Disease on Dialysis","enrollment":34},{"nctId":"NCT06362668","phase":"NA","title":"EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System (FASTR-EU)","status":"COMPLETED","sponsor":"Reprieve Cardiovascular, Inc","startDate":"2024-05-17","conditions":"Acute Decompensated Heart Failure","enrollment":12},{"nctId":"NCT05652322","phase":"PHASE2, PHASE3","title":"Prolonged Intravenous Therapy Versus Early Initiation of an Oral Loop Diuretic in Decompensated Heart Failure","status":"WITHDRAWN","sponsor":"Jan Kochanowski University","startDate":"2022-12-07","conditions":"Heart Failure","enrollment":""},{"nctId":"NCT05986773","phase":"PHASE4","title":"Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance","status":"TERMINATED","sponsor":"Stadtspital Zürich","startDate":"2023-10-10","conditions":"Acute Heart Failure, Diuretic Resistance","enrollment":13},{"nctId":"NCT04170855","phase":"NA","title":"Kidney Sodium Content in Cardiorenal Patients","status":"RECRUITING","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2020-10-20","conditions":"Cardio-Renal Syndrome","enrollment":50},{"nctId":"NCT04180397","phase":"PHASE4","title":"Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.","status":"RECRUITING","sponsor":"Morten H. Bestle","startDate":"2020-08-17","conditions":"Fluid Overload","enrollment":1000},{"nctId":"NCT06786728","phase":"NA","title":"Decongestion Guided By VExUS Score Or Lung Ultrasound For Renal Recovery In Patients With Cardiorenal Syndrome Type -1","status":"ENROLLING_BY_INVITATION","sponsor":"Benha University","startDate":"2024-08-10","conditions":"Cardiorenal Syndrome Type 1","enrollment":146},{"nctId":"NCT05079789","phase":"PHASE3","title":"Amiloride in Nephrotic Syndrome","status":"TERMINATED","sponsor":"University Hospital Tuebingen","startDate":"2020-06-08","conditions":"Nephrotic Syndrome, Edema, Sodium Retention","enrollment":20},{"nctId":"NCT06750575","phase":"","title":"Study to Examine the Effect of the Diuretic Furosemide on the Plasma Levels of Toxins and the Removal of Toxins from the Blood in Patients with Chronic Kidney Disease","status":"RECRUITING","sponsor":"UMC Utrecht","startDate":"2024-06-10","conditions":"Chronic Kidney Diseases, Renal Failure Chronic","enrollment":34},{"nctId":"NCT05276219","phase":"PHASE4","title":"Optimized Treatment of Pulmonary Edema or Congestion","status":"RECRUITING","sponsor":"Johannes Grand","startDate":"2023-09-14","conditions":"Pulmonary Edema, Congestive Heart Failure, Acute Heart Failure","enrollment":1104},{"nctId":"NCT05105009","phase":"PHASE1","title":"Furosemide and Creatinine Tubular Stress Test in Order to Measure Proximal Tubule Residual Function","status":"COMPLETED","sponsor":"Instituto Nacional de Cardiologia Ignacio Chavez","startDate":"2020-03-03","conditions":"Chronic Kidney Failure","enrollment":50},{"nctId":"NCT06377449","phase":"NA","title":"Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients","status":"RECRUITING","sponsor":"Saint Petersburg State University, Russia","startDate":"2024-05-15","conditions":"Ischemic Heart Disease, Aortic Stenosis, Severe, Aortic Insufficiency","enrollment":186},{"nctId":"NCT05093621","phase":"PHASE3","title":"Torsemide Comparison With Furosemide for Management of Patients With Stable Heart Failure","status":"COMPLETED","sponsor":"Yale University","startDate":"2021-02-08","conditions":"Heart Failure","enrollment":47},{"nctId":"NCT00690521","phase":"NA","title":"A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients","status":"COMPLETED","sponsor":"University of New Mexico","startDate":"2004-10-26","conditions":"Congestive Heart Failure","enrollment":8},{"nctId":"NCT06630923","phase":"PHASE3","title":"PREVENTION OF WORSENING RENAL FUNCTION OF INTRAVENUS ALBUMIN IN HEART FAILURE PATIENTS","status":"RECRUITING","sponsor":"Democritus University of Thrace","startDate":"2023-01-14","conditions":"Diuretics Drug Reactions, Heart Failure; With Decompensation, Albumin; Double","enrollment":250},{"nctId":"NCT02163655","phase":"PHASE4","title":"Diuretics for Postpartum High Blood Pressure in Preeclampsia","status":"COMPLETED","sponsor":"Instituto Materno Infantil Prof. Fernando Figueira","startDate":"2014-06-20","conditions":"Preeclampsia","enrollment":120},{"nctId":"NCT06586060","phase":"NA","title":"Lung Ultrasound Guided Fluid Balance Strategy in Patients with Lung Contusion","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-10","conditions":"Lung Contusion","enrollment":100},{"nctId":"NCT03259165","phase":"PHASE2","title":"Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial","status":"TERMINATED","sponsor":"Indiana University","startDate":"2017-12-14","conditions":"Heart Failure, Heart Failure Acute, Acute Cardiac Failure","enrollment":52},{"nctId":"NCT06535529","phase":"PHASE3","title":"Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients","status":"RECRUITING","sponsor":"Helwan University","startDate":"2024-08-24","conditions":"Acute Decompensated Heart Failure","enrollment":60},{"nctId":"NCT06414759","phase":"PHASE4","title":"Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload","status":"RECRUITING","sponsor":"Cairo University","startDate":"2024-07-01","conditions":"Acute Decompensated Heart Failure, Volume Overload, Edema","enrollment":110},{"nctId":"NCT05962255","phase":"PHASE3","title":"Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure","status":"COMPLETED","sponsor":"Wroclaw Medical University","startDate":"2022-02-01","conditions":"Acute Heart Failure, Congestion, Heart Failure","enrollment":50},{"nctId":"NCT03136198","phase":"PHASE2","title":"B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure Pilot Trial","status":"COMPLETED","sponsor":"Indiana University","startDate":"2017-07-10","conditions":"Heart Failure, Heart Failure Acute, Acute Cardiac Pulmonary Edema","enrollment":130},{"nctId":"NCT05904808","phase":"PHASE4","title":"The Heart Failure Diuresis Efficacy Comparison (DEA-HF) Study","status":"COMPLETED","sponsor":"Rambam Health Care Campus","startDate":"2023-04-19","conditions":"Chronic Heart Failure, Diuretics Drug Reactions, Congestive Heart Failure","enrollment":42},{"nctId":"NCT04615624","phase":"PHASE3","title":"Furosemide vs. Placebo for Severe Antepartum Hypertension","status":"COMPLETED","sponsor":"Melanie Maykin, MD","startDate":"2021-01-04","conditions":"Pre-Eclampsia, Hypertension in Pregnancy, Pregnancy Complications","enrollment":65},{"nctId":"NCT06326112","phase":"PHASE2","title":"Role of Active Deresuscitation After Resuscitation:","status":"NOT_YET_RECRUITING","sponsor":"Unity Health Toronto","startDate":"2024-05-01","conditions":"Fluid Overload, Critical Illness, Sepsis","enrollment":120},{"nctId":"NCT04298229","phase":"PHASE3","title":"Efficacy and Safety of Dapagliflozin in Acute Heart Failure","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2020-04-01","conditions":"Heart Failure, Diabetes Mellitus, Type 2","enrollment":240},{"nctId":"NCT06218199","phase":"PHASE4","title":"Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts","status":"RECRUITING","sponsor":"Heart Center Research, LLC","startDate":"2021-07-08","conditions":"Heart Failure, Congestive","enrollment":80},{"nctId":"NCT05752097","phase":"","title":"[18F]AlF-NOTA-FAPI-04 PET/CT in Inflammation and Fibrosis in Renal Diseases","status":"UNKNOWN","sponsor":"Sichuan Provincial People's Hospital","startDate":"2023-02-01","conditions":"18F-FAPI PET/CT Examination, Renal Puncture Biopsy","enrollment":30},{"nctId":"NCT06203236","phase":"PHASE4","title":"Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2024-01","conditions":"Acute Heart Failure, Chronic Kidney Diseases","enrollment":300},{"nctId":"NCT05382598","phase":"NA","title":"Timing of Renal Replacement Therapy In Mechanically Ventilated Patients","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2022-06-28","conditions":"Timing of RRT in Mechanically Ventilated Patients","enrollment":94},{"nctId":"NCT05287100","phase":"NA","title":"To Assess the Efficacy of Midodrine in Prevention of Cirrhosis Related Complications in Children Awaiting Liver Transplantation.","status":"COMPLETED","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2022-01-01","conditions":"Cirrhosis, Liver","enrollment":35},{"nctId":"NCT05620784","phase":"PHASE3","title":"Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2023-03-01","conditions":"BPH With Urinary Obstruction, BPH, Hematuria","enrollment":138},{"nctId":"NCT05538234","phase":"","title":"Biomarkers of Kidney Function in Transplant Medicine","status":"RECRUITING","sponsor":"University Hospital Ostrava","startDate":"2023-01-01","conditions":"Acute Kidney Injury","enrollment":30},{"nctId":"NCT01474200","phase":"NA","title":"Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment","status":"TERMINATED","sponsor":"Nuwellis, Inc.","startDate":"2012-01","conditions":"Heart Failure, Cardiac Failure, Acute Decompensated Heart Failure (ADHF)","enrollment":224},{"nctId":"NCT05940220","phase":"PHASE3","title":"Efficacy of Oral Acetazolamide in Decongestion in Patients With Heart Failure","status":"UNKNOWN","sponsor":"Tehran University of Medical Sciences","startDate":"2023-12-30","conditions":"Heart Failure","enrollment":130},{"nctId":"NCT05933642","phase":"PHASE2, PHASE3","title":"Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults","status":"UNKNOWN","sponsor":"University of Malaya","startDate":"2023-07-02","conditions":"Acute Kidney Injury","enrollment":132},{"nctId":"NCT01275729","phase":"NA","title":"The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury","status":"COMPLETED","sponsor":"University of Chicago","startDate":"2010-12","conditions":"Acute Kidney Failure","enrollment":96},{"nctId":"NCT05298098","phase":"NA","title":"Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure","status":"UNKNOWN","sponsor":"University of Monastir","startDate":"2018-07-01","conditions":"Acute Decompensated Heart Failure","enrollment":600},{"nctId":"NCT05158153","phase":"PHASE4","title":"Outpatient Recovery From Acute Kidney Injury Requiring Dialysis","status":"TERMINATED","sponsor":"University of California, San Francisco","startDate":"2021-10-18","conditions":"Acute Kidney Injury, Dialysis Hypotension","enrollment":1},{"nctId":"NCT05840536","phase":"PHASE4","title":"Combination Diuretic Therapy for Acute Decompensated Heart Failure","status":"WITHDRAWN","sponsor":"Ochsner Health System","startDate":"2014-05","conditions":"Acute Decompensated Heart Failure","enrollment":""},{"nctId":"NCT05807152","phase":"NA","title":"Furosemide-induced Diuresis With Matched Dehydration Compared to Standard Diuretic Therapy in Patients With Acute Heart Failure and Overt Fluid Overload","status":"UNKNOWN","sponsor":"Centro Cardiologico Monzino","startDate":"2019-02-19","conditions":"Acute Decompensated Heart Failure","enrollment":170},{"nctId":"NCT05769738","phase":"PHASE3","title":"The Addition of Inhaled Furosemide to Standard Treatment of COPD Exacerbation","status":"UNKNOWN","sponsor":"American University of Beirut Medical Center","startDate":"2023-03","conditions":"Chronic Obstructive Pulmonary Disease Exacerbation, COPD Exacerbation","enrollment":200},{"nctId":"NCT05594823","phase":"PHASE4","title":"Flexible vs. Fixed Diuretic Regimen in the Management of Chronic Heart Failure: A Pilot Study","status":"UNKNOWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2023-01-03","conditions":"Heart Failure, Heart Diseases","enrollment":30},{"nctId":"NCT03458325","phase":"PHASE3","title":"Furoscix Real-World Evaluation for Decreasing Hospital Admissions in Heart Failure","status":"COMPLETED","sponsor":"scPharmaceuticals, Inc.","startDate":"2020-11-12","conditions":"Heart Failure","enrollment":27},{"nctId":"NCT05087940","phase":"","title":"Treatment of Resistant Hypertension: Cohort Study","status":"COMPLETED","sponsor":"Galenika AD Beograd","startDate":"2021-06-01","conditions":"Resistant Hypertension","enrollment":731},{"nctId":"NCT03750136","phase":"NA","title":"Furosemide Alone or Unexpectedly With Solution of Hypertonic Saline in Nephrotic Syndrome","status":"UNKNOWN","sponsor":"Medical University of Bialystok","startDate":"2018-12-15","conditions":"Nephrotic Syndrome","enrollment":30},{"nctId":"NCT05580510","phase":"PHASE2, PHASE3","title":"\" Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD \"","status":"UNKNOWN","sponsor":"Instituto Nacional de Cardiologia Ignacio Chavez","startDate":"2023-02-06","conditions":"Congenital Heart Disease, Heart Failure, Heart Failure With Reduced Ejection Fraction","enrollment":160},{"nctId":"NCT04331132","phase":"NA","title":"Tolvaptan add-on Therapy to Overcome Loop Diuretic Resistance in Acute Heart Failure With Renal Dysfunction","status":"UNKNOWN","sponsor":"Gia Dinh People Hospital","startDate":"2021-12-01","conditions":"Acute Heart Failure","enrollment":128},{"nctId":"NCT01156220","phase":"PHASE4","title":"Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers","status":"WITHDRAWN","sponsor":"Universitätsklinikum Hamburg-Eppendorf","startDate":"2012-01","conditions":"Healthy Male and Female Volunteers","enrollment":""},{"nctId":"NCT04622709","phase":"PHASE2","title":"Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2020-10-07","conditions":"Chronic Kidney Disease Requiring Chronic Dialysis","enrollment":39},{"nctId":"NCT05379257","phase":"NA","title":"A Feasibility Non-inferiority Clinical Trial for Dosing of Diuretics in CHF Patients","status":"UNKNOWN","sponsor":"Hadassah Medical Organization","startDate":"2020-01-20","conditions":"Congestive Heart Failure","enrollment":12},{"nctId":"NCT04763226","phase":"PHASE1","title":"A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986308 in Healthy Participants","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"2021-04-14","conditions":"Healthy Participants","enrollment":46},{"nctId":"NCT05304702","phase":"","title":"Lung Injury (Pulmonary Edema) in COVID-19: Treatment With Furosemide and Negative Fluid Balance (NEGBAL)","status":"COMPLETED","sponsor":"Clinica Colon","startDate":"2021-11-28","conditions":"COVID-19","enrollment":120},{"nctId":"NCT03512392","phase":"NA","title":"Role of Active Deresuscitation After Resuscitation-2","status":"COMPLETED","sponsor":"Belfast Health and Social Care Trust","startDate":"2018-04-10","conditions":"Critical Illness, Sepsis, Trauma","enrollment":180},{"nctId":"NCT04235062","phase":"NA","title":"NATriuretic Response to Expansion and dIUretics in huMans With Heart Failure","status":"COMPLETED","sponsor":"Momentum Research, Inc.","startDate":"2020-04-01","conditions":"Heart Failure","enrollment":229},{"nctId":"NCT04385589","phase":"PHASE4","title":"Dapagliflozin in Diabetic Patients (Type 2) With Decompensated Heart Failure","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-05-01","conditions":"Heart Failure","enrollment":100},{"nctId":"NCT04192110","phase":"PHASE4","title":"Association of Diuretics With Change in Extracellular Volume, Natriuretic Peptides, Symptoms, and Cardiovascular Outcomes in CKD","status":"WITHDRAWN","sponsor":"VA Office of Research and Development","startDate":"2020-08-11","conditions":"Chronic Kidney Disease","enrollment":""},{"nctId":"NCT03746002","phase":"PHASE4","title":"Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing","status":"TERMINATED","sponsor":"University of Maryland, Baltimore","startDate":"2019-01-01","conditions":"Fluid Overload, Heart Failure Acute","enrollment":3},{"nctId":"NCT04496583","phase":"NA","title":"Fluid unLoading On Weaning (FLOW)","status":"UNKNOWN","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2021-07-01","conditions":"Weaning Failure, Fluid Overload, Cardiac Failure Acute","enrollment":46},{"nctId":"NCT04572867","phase":"NA","title":"Aquapheresis Efficacy in Outpatients With Decompensated Heart Failure","status":"WITHDRAWN","sponsor":"Ramona Gelzer Bell","startDate":"2021-06-08","conditions":"Heart Failure, Congestive Heart Failure, Decompensated Heart Failure","enrollment":""},{"nctId":"NCT02345681","phase":"PHASE3","title":"Impact of Rational Control of Fluid Balance in the Intensive Care Unit","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2015-05","conditions":"Fluid Balance of ICU Patients, Fluid Overload","enrollment":171},{"nctId":"NCT03226457","phase":"PHASE4","title":"SGLT2 Inhibition in Combination With Diuretics in Heart Failure","status":"COMPLETED","sponsor":"University of Dundee","startDate":"2017-12-11","conditions":"Heart Failure, Type 2 Diabetes Mellitus","enrollment":23},{"nctId":"NCT04182854","phase":"NA","title":"Use of Diuretics in Maintenance Hemodialysis Patients Undergoing Bioimpedance-guided Fluid Management","status":"UNKNOWN","sponsor":"Capital Medical University","startDate":"2019-10-28","conditions":"Diuretic Abuse","enrollment":46},{"nctId":"NCT04907123","phase":"PHASE3","title":"Systematic Escalation of diuREtics With Natriuresis in Heart Failure Patients: SERENA Trial","status":"UNKNOWN","sponsor":"University of Turin, Italy","startDate":"2021-10","conditions":"Heart Failure","enrollment":198}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"COMPLETED SUICIDE"},{"count":1,"reaction":"COUGH"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lasix"],"phase":"marketed","status":"active","brandName":"Furosemide (Diuretic)","genericName":"Furosemide (Diuretic)","companyName":"Jose J Zaragoza, MD MSc","companyId":"jose-j-zaragoza-md-msc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Furosemide inhibits sodium and chloride reabsorption in the thick ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes. Used for Edema associated with congestive heart failure, Edema associated with hepatic cirrhosis, Edema associated with renal disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}