{"id":"furosemide-and-matched-saline-hydration","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hyperuricemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination therapy uses furosemide to reduce excess fluid volume and congestion, particularly in heart failure or acute decompensated states, while matched saline hydration simultaneously replaces intravascular volume to prevent hypotension and preserve renal perfusion. The strategy aims to achieve decongestion without inducing cardiorenal syndrome or worsening renal function, a concept sometimes referred to as 'diuresis with matched hydration' in cardiology.","oneSentence":"Furosemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting fluid excretion, while saline hydration provides intravenous fluid replacement to maintain hemodynamic stability.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:47:10.871Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute decompensated heart failure with fluid overload"},{"name":"Cardiorenal syndrome prevention during diuresis"}]},"trialDetails":[{"nctId":"NCT01098032","phase":"PHASE3","title":"RenalGuard System and Contrast Media","status":"COMPLETED","sponsor":"Clinica Mediterranea","startDate":"2009-01","conditions":"Chronic Kidney Disease","enrollment":294},{"nctId":"NCT00702728","phase":"PHASE3","title":"Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy (CIN) Prevention","status":"UNKNOWN","sponsor":"Centro Cardiologico Monzino","startDate":"2008-06","conditions":"Contrast Induced Nephropathy","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Furosemide and matched saline hydration","genericName":"Furosemide and matched saline hydration","companyName":"Centro Cardiologico Monzino","companyId":"centro-cardiologico-monzino","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Furosemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting fluid excretion, while saline hydration provides intravenous fluid replacement to maintain hemodynamic stability. Used for Acute decompensated heart failure with fluid overload, Cardiorenal syndrome prevention during diuresis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}