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Together, this combination targets both the estrogen receptor pathway and cell cycle checkpoints, providing complementary mechanisms to overcome resistance and improve efficacy in hormone receptor-positive breast cancer.","oneSentence":"Fulvestrant blocks estrogen receptors while abemaciclib inhibits CDK4/6, together suppressing hormone-driven breast cancer cell growth through dual pathway inhibition.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:47:09.615Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hormone receptor-positive, HER2-negative advanced or metastatic breast cancer"}]},"trialDetails":[{"nctId":"NCT05307705","phase":"PHASE1","title":"A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2022-05-11","conditions":"Breast Cancer","enrollment":193},{"nctId":"NCT07174336","phase":"PHASE3","title":"A Study of Tersolisib 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