{"id":"frusemide","rwe":[],"tags":[],"safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[],"contraindications":["Anuria","Azotemia","Benign prostatic hyperplasia","Bladder outflow obstruction","Cardiogenic shock","Diabetes mellitus","Gout","Hearing disorder","Hyperuricemia","Hypocalcemia","Hypochloremia","Hypokalemia","Hypomagnesemia","Hyponatremia","Hypovolemia","Low blood pressure","Metabolic alkalosis","Myocardial infarction","Orthostatic hypotension","Pancreatitis","Systemic lupus erythematosus"],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"trials":[],"_chembl":{"chemblId":"CHEMBL35","moleculeType":"Small molecule","molecularWeight":"330.75"},"aliases":["Lasix","spironolactone","hydrochlorothiazide","Rosiglitazone"],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Frusemide","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:17:12.669748+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Frusemide","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T01:17:21.017770+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T01:17:26.217245+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:17:19.563014+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Frusemide","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:17:19.913946+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Sodium-(potassium)-chloride cotransporter 2 inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:17:21.009437+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL35/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:17:20.627722+00:00"}},"offLabel":[],"timeline":[],"_dailymed":null,"aiSummary":"Frusemide, marketed by Melbourne Health, is an established treatment for acute pulmonary edema. The drug's key composition patent is set to expire in 2028, providing a period of market exclusivity. The primary risk is the potential increase in competition following patent expiry.","ecosystem":[],"mechanism":{"target":"ATP-binding cassette sub-family G member 2, CDGSH iron-sulfur domain-containing protein 1, G-protein coupled receptor 35"},"_scrapedAt":"2026-03-27T23:30:51.453Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Furosemide","title":"Furosemide","extract":"Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. Furosemide may also be used for the treatment of high blood pressure. It can be taken intravenously or orally. When given intravenously, furosemide typically takes effect within five minutes; when taken orally, it typically metabolizes within an hour."},"references":[],"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T01:17:26.217335+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"indications":{"approved":[{"name":"Acute pulmonary edema","diseaseId":"acute-pulmonary-edema","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Decompensated cardiac failure","diseaseId":"decompensated-cardiac-failure","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Edema","diseaseId":"edema","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Edema due to Hepatic 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